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Adjunctive antibiotic therapy in cases of periodontitis and peri-implantitis

Elitsa Sabeva



Periodontitis and peri-implantitis are plaque-induced diseases, which are associated with certain bacteria. The conventional treatment aims primarily at tooth or implant surface debridement. In certain cases, surgical therapy is necessary. To improve the outcome of the treatment, systemic or topical antibiotics could be considered.


The aim of this review is to investigate the effect of the adjunctive systemically or topically delivered antibiotics on the outcome of the periodontitis and peri-implantitis treatment.

Materials and Methods

Articles related to the topic were searched in the PubMed database. Articles published from 2000 to 2019, only in English language, were included in the review. The search was conducted with a variety of keywords in different combinations being used. These were: “periodontitis”, “peri-implantitis”, “antibiotic”, “local”, “metronidazole”, “amoxicillin”, “azithromycin”, “tetracycline”.


Forty-seven articles were included in the review. The selected articles described the adjunctive systemic and/or local delivery of metronidazole, azithromycin, the combination of metronidazole and amoxicillin and some representatives of the tetracycline group, such as doxycycline and minocycline in cases of periodontitis and peri-implantitis.


The adjunctive systemic and topical antibiotic therapy could benefit the outcome of periodontitis and peri-implantitis treatment.


antibiotic, peri-implantitis, periodontitis, treatment

Full Text


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About The Author

Elitsa Sabeva
Medical University of Varna

Department of Periodontology and Dental Implantology, Faculty of Dental Medicine

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