Introduction: Lichen planus is the most common mucocutaneous autoimmune inflammatory disease of the skin and/or mucous membranes. It is a Т-cell-mediated immune response of hypersensitivity to self-intraepithelial antigens of the skin and mucous membranes. The oral lichen planus is more common than the cutaneous one. The etiology of the disease is unknown and the main clinical feature of lichen planus is a reticular hyperkeratotic lesion—the Wickham’s striae. The diagnosis of the disease is based on clinical, histopathological results and immunological data.
Aim: The aim of this review article is to summarize the clinical features of different forms of oral lichen planus and their diagnosis in dental practice.
Materials and Methods: The review is based on the summary of previous and latest updates of different researches in the years.
Conclusion: The role of dental clinician can be crucial for early diagnosis of lichen planus. The understanding of the clinical symptoms and diagnosis of this disease are important for the accurate treatment of lesions.
Mehrotra V, Devi P, Bhovi TV, Jyoti B. Mouth as a mirror of systemic diseases. Gomal J Med Sci. 2010;8:235–41.
Canto AM, Müller H, Freitas RR, Santos PS. Oral lichen planus (OLP): clinical and complementary diagnosis.An Bras Dermatol. 2010;85(5):669-75. doi: 10.1590/s0365-05962010000500010.
Edwards PC, Kelsch R. Oral lichen planus: clinical presentation and management. J Can Dent Assoc. 2002;68(8):494-9.
Boorghani M, Gholizadeh N, Taghavi Zenouz A, Vatankhah M, Mehdipour M. Oral lichen planus: clinical features, etiology, treatment and management; a review of literature. J Dent Res Dent Clin Dent Prospects. 2010;4(1):3-9. doi: 10.5681/joddd.2010. 002.
Setterfield JF, Black MM, Challacombe SJ. The management of oral lichen planus. Clin Exp Dermatol. 2000;25(3):176–182. doi: 10.1046/j.1365-2230.2000.00607.
Ishii T. Immunohistochemical demonstration of T cell subsets and accessory cells in oral lichen planus. J Oral Pathol. 1987;16(7):356–361. doi: 10.1111/j.1600-0714.1987.tb00708.
Malmstrom M, Konttinen YT, Jungell P, Bergroth V, Segerberg-Konttinen M, Nordström D. Lymphocyte activation in oral lichen planus in situ. Am J Clin Pathol. 1988 Mar; 89(3):329-34. doi: 10.1093/ajcp/89.3.329.
Eversole LR. Immunopathogenesis of oral lichen planus and recurrent aphthous stomatitis. Semin Cutan Med Surg. 1997 Dec;16(4):284-94. doi: 10.1016/s1085-5629(97)80018-1.
Kurago ZB. Etiology and pathogenesis of oral lichen planus: an overview. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016; 122(1):72–80. doi: 10.1016/j.oooo.2016.03.011.
Keteva A, Boykova Y, Koynova I, Balcheva M. Correlation between oral lichen planus and thyroid disease. Scripta Scientifica Vox Studentium 2018, 2, 48, doi:10.14748/ssvs.v2i0.4690.
Li D, Li J, Li C, Chen Q, Hua H. The Association of Thyroid Disease and Oral Lichen Planus: A Literature Review and Meta-analysis. Front Endocrinol (Lausanne). 2017;8:310. doi:10.3389/fendo.2017.00310.
Asarch A, Gottlieb AB, Lee J, Masterpol KS, Scheinman PL, Stadecker MJ, et al. Lichen planus-like eruptions: an emerging side effect of tumor necrosis factor-alpha antagonists. J. Am. Acad. Dermatol. 2009;61(1):104-11. doi: 10.1016/j.jaad.2008.09.032.
Scully C, Beyli M, Ferreiro MC, Ficarra G, Gill Y, Griffiths M, et al. Update on oral lichen planus: etiopathogenesis and management. Crit Rev Oral Biol Med. 1998;9(1):86-122. doi: 10.1177/10454411980090010501.
Giannetti L, Dello Diago AM, Spinas E. Oral Lichen planus. J Biol Regul Homeost Agents. 2018;32(2):391-5.
Shiohara T, Moriya N, Mochizuki T, Nagashima M. Lichenoid tissue reaction (LTR) induced by local transfer of Ia-reactive T-cell clones. II. LTR by epidermal invasion of cytotoxic lymphokine-producing autoreactive T cells. J Invest Dermatol. 1987;89(1):8-14.
Holmstrup P, Thorn JJ, Rindum J, Pindborg JJ. Malignant development of lichen planus-affected oral mucosa. J Oral Pathol. 1988;17(5):219-25. doi: 10.1111/j.1600-0714.1988.tb01528.x
Mattson U, Jontell M, Holmstrup P. Oral lichen planus malignant transformation: Is a recall of patients justified? Crit Rev Oral Biol Med. 2002;13(5):390-6. doi: 10.1177/154411130201300503.
Ingafou M, Leao JC, Porter SR, Scully C. Oral lichen planus: A retrospective study of 690 British patients. Oral Dis. 2006;12(5):463-8. doi: 10.1111/j.1601-0825.2005. 01221.x.
Andreasen JO. Oral lichen planus. 1. A clinical evaluation of 115 cases. Oral Surg Oral Med Oral Pathol. 1968;25(1):31-42. doi: 10.1016/0030-4220(68)90194-1.
Axell T, Rundquist L. Oral lichen planus - а demographic study. Community Dent Oral Epidemiol. 1987;15(1):52-6. doi: 10.1111/j.1600-0528.1987.tb00480.x.
Cheng YS, Gould A, Kurago Z, Fantasia J, Muller S. Diagnosis of oral lichen planus: a position paper of the American Academy of Oral and Maxillofacial Pathology. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016; 122(3):332-54. doi: 10.1016/j.oooo.2016.05.004.
Georgieva I. Candidiasis-oral manifestations: a literature review. IJSR. 2021; 10(9):568-71 doi: 10.21275/SR21911014956.
Jana A, Thomas J, Ghosh P. Erosive oral lichen planus inflicts higher cellular stress than reticular type. J Oral Maxillofac Pathol. 2021;25(2):279-85. doi:10.4103/0973-029X.325127.
Misra SR, Baskaran P, Maragathavalli G. Ulcerated oral lichen planus of the lower lip, common disease with the uncommon presentation: A case series. J Family Med Prim Care. 2020;9(5):2505-8. Published 2020 May 31. doi:10.4103/jfmpc.jfmpc_19_20.
Pock L, Jelinkova L, Drlik L, Abrhamova S, Vojtechovska S, Sezemska D, et al. Lichen planus pigmentosusinversus. J Eur Acad Dermatol Venereol. 2001;15(5):452–4. doi: 10.1046/j.1468-3083.2001.00347.x.
Guertlera A, Evenschora N, Seegraebera M, French L, Weilerc V, Flaiga M, et al. Lichen planus pigmentosus inversus: a rare subvariant of lichen planus pigmentosus. Case Rep Dermatol. 2021;13:407–10. doi: 10.1159/000515735.
Gupta S, Jawanda MK. Oral lichen planus: an update on etiology, pathogenesis, clinical presentation, diagnosis and management. Indian J Dermatol. 2015; 60(3):222-9. doi: 10.4103/0019-5154.156315.
Yang JY, Tan YQ, Zhou G. T cell-derived exosomes containing cytokines induced keratinocytes apoptosis in oral lichen planus. Oral Dis. 2022; 28(3):682-90. doi: 10.1111/odi.13795. Epub 2021 Feb 16.
Roopashree MR, Gondhalekar RV, Shashikanth MC, George J, Thippeswamy SH, Shukla A. Pathogenesis of oral lichen planus--a review. J Oral Pathol Med. 2010;39(10):729-34. doi: 10.1111/j.1600-0714.2010.00946.x.
Hashimoto K, Dibella RJ, Shklar G, Lever WF. Electron microscopic studies of oral lichen planus. G Ital Dermatol Minerva Dermatol. 1966;107(5):765-88.
Camisa C, Allen C, Bowen B, Olsen R. Indirect immunofluorescence of oral lichen planus. J Oral Pathol Med. 1986;15(4):218-20.
Shekar C, Ganesan S. Oral lichen planus: Review. J Dent Sci Res. 2011;2(1):62–87.
Cook LC, Hanna C, Foulke GT, Seiverling EV. Dermoscopy in the diagnosis of inflammatory dermatoses:systematic review findings reported for psoriasis, lupus, and lichen planus. J Clin Aesthet Dermatol. 2018;11(4):41-2.
Lavanya N, Jayanthi P, Rao UK, Ranganathan K. Oral lichen planus: An update on pathogenesis and treatment. J Oral Maxillofac Pathol. 2011;15(2):127-32. doi: 10.4103/0973-029X.84474.
Thornhill M, Sankar V, Xu X, Barrett A, High A, Odell EW, et al. The role of histopathological characteristics in distinguishing amalgam-associated oral lichenoid reactions and oral lichen planus. J Oral Pathol Med. 2006;35(4):233-40. doi: 10.1111/j.1600-0714.2006.00406.x.
Scully C, Monteil R, Sposto MR. Infectious and tropical diseases affecting the human mouth. Periodontol 2000. 1998;18:47-70. doi: 10.1111/j.1600-0757.1998.tb00138.x.
Ismail SB, Kumar SK, Zain RB. Oral lichen planus and lichenoid reactions: etiopathogenesis, diagnosis, management and malignant transformation. J Oral Sci. 2007;49(2):89–106. doi: 10.2334/josnusd.49.89.
Halevy S, Shai A. Lichenoid drug eruptions. J Am Acad Dermatol. 1993;29(2 Pt 1):249-55. doi: 10.1016/0190-9622(93)70176-t.
Dudhia BB, Dudhia SB, Patel PS, Jani YV. Oral lichen planus to oral lichenoid lesions: Evolution or revolution. J Oral Maxillofac Pathol. 2015;19(3):364-70. doi:10.4103/0973-029X.174632.
Fujii H, Ohashi M, Nagura H. Immunohistochemical analysis of oral lichen planus-like eruption in graft-versus-host disease after allogeneic bone marrow transplantation. Am J Clin Pathol. 1988; 89(2):177-86. doi: 10.1093/ajcp/89.2.177.
Carrozzo M, Gandolfo S. Oral diseases possibly associated with hepatitis C virus. Crit Rev Oral Biol Med. 2003;14(2):115-27. doi: 10.1177/154411130301400205.
Scelza G, Amato A, Pagano AM, Matteis G, Caruso R, Scelza A, et al. Effect of hepatitis C antiviral therapy on oral lichen planus and hyposalivation in inmates. Ann Gastroenterol. 2022;35(1):74-9. doi:10.20524/aog.2021.0672. Epub 2021 Nov 10.
Silverman S, Jr, Bahl S. Oral lichen planus update: clinical characteristics, treatment responses, and malignant transformation. Am J Dent. 1997;10(6):259–63.
Eisenberg E. Lichen planus and oral cancer: is there a connection between the two?J Am Dent Assoc. 1992;123(5):104–8. doi: 10.14219/jada.archive.1992.0114.
Gonzalez-Moles MA, Scully C, Gil-Montoya JA. Oral lichen planus: controversies surrounding malignant transformation. Oral Dis. 2008;14(3):229-43. doi: 10.1111/j.1601-0825.2008.01441.x.
Farhi D, Dupin N. Pathophysiology, etiologic factors, and clinical management of oral lichen planus, part I: facts and controversies. Clin Dermatol. 2010;28(1):100-8. doi: 10.1016/j.clindermatol.2009.03.004.
Balasubramaniam P, Ogboli M, Moss C. Lichen planus in children: review of 26 cases. Clin Exp Dermatol. 2008;33(4):457-9. doi: 10.1111/j.1365-2230.2008.02694.x.