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Glandular odontogenic cyst—a review of characteristic features, treatment, and recurrence

Varvara-Velika Rogova, Tihomir Georgiev


INTRODUCTION: The glandular odontogenic cyst is classified as a developmental epithelial odontogenic cyst and defined as “arising in the tooth-bearing areas of the jaws and characterized by an epithelial lining with cuboidal or columnar cells both at the surface and lining crypts or cyst-like spaces within the thickness of the epithelium”.
AIM: This review outlines the epidemiology, clinical and radiological presentation, histological characteristics, additional markers aiding in the correct diagnosis, treatment modalities, and recurrence rates of glandular odontogenic cysts.
MATERIALS AND METHODS: For the purpose of this review, literature reviews and case reports with included literature reviews from the Scopus, PubMed, and ScienceDirect databases were used. The bibliography of the selected articles was additionally analyzed.
RESULTS: The glandular odontogenic cyst is a relatively rare entity, clinically and radiographically non-specific. It is often misdiagnosed because of its overlapping histopathological features with other odontogenic cysts such as lateral periodontal or botryoid cyst, dentigerous and radicular cysts with mucous metaplasia, and central mucoepidermoid carcinoma. Regarding the treatment, both conservative and radical methods may be applied. These cysts have a high propensity for recurrence and display an aggressive behavior.
CONCLUSION: Clinically and radiographically glandular odontogenic cysts can resemble several other lesions of the jaws, which denotes the importance of a precise histopathological diagnosis. The choice of treatment should be based on the degree of aggressive behavior of the cyst. Meticulous examination, appropriate treatment planning, and sufficient follow-up periods are key to a successful outcome.


glandular odontogenic cyst; odontogenic cyst

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Padayachee A, Van Wyk CW. Two cystic lesions with features of both the botryoid odontogenic cyst and the central mucoepidermoid tumour: sialo-odontogenic cyst? J Oral Pathol. 1987;16(10):499-504. doi: 10.1111/j.1600-0714.1987.tb00680.x.

Gardner DG, Kessler HP, Morency R, Schaffner DL. The glandular odontogenic cyst: an apparent entity. J Oral Pathol. 1988;17(8):359-66. doi: 10.1111/j.1600-0714.1988.tb01298.x.

Kramer IR, Pindborg JJ, Shear M. The WHO histological typing of odontogenic tumours. a commentary on the second edition. Cancer. 1992;70(12):2988-94. doi: 10.1002/1097-0142(19921215)70:12<2988::aid-cncr2820701242>;2-v.

Anchlia S, Bahl S, Shah V, Vyas S. Glandular odontogenic cyst: a rare entity revealed and a review of the literature. BMJ Case Rep. 2015;2015:bcr2015211502. doi: 10.1136/bcr-2015-211502

Magnusson B, Göransson L, Odesjö B, Gröndahl K, Hirsch JM. Glandular odontogenic cyst. Report of seven cases. Dentomaxillofac Radiol. 1997;26(1):26-31. doi: 10.1038/sj.dmfr.4600205.

van Heerden WF, Raubenheimer EJ, Turner ML. Glandular odontogenic cyst. Head Neck. 1992;14(4):316-20. doi: 10.1002/hed.2880140412.

Nel C, Robinson L, Roza ALOC, Ker-Fox J, Gomes NR, Fonseca FP, et al. Clinical and radiologic spectrum of glandular odontogenic cysts: A multicenter study of 92 cases. Oral Surg Oral Med Oral Pathol Oral Radiol. 2022;133(5):593-603. doi: 10.1016/j.oooo.2021.11.008.

Fowler CB, Brannon RB, Kessler HP, Castle JT, Kahn MA. Glandular odontogenic cyst: analysis of 46 cases with special emphasis on microscopic criteria for diagnosis. Head Neck Pathol. 2011;5(4):364-75. doi:10.1007/s12105-011-0298-3.

Faisal M, Ahmad SA, Ansari U. Glandular odontogenic cyst - Literature review and report of a paediatric case. J Oral Biol Craniofac Res. 2015;5(3):219-25. doi:10.1016/j.jobcr.2015.06.011.

MacDonald-Jankowski DS. Glandular odontogenic cyst: Systematic review. Dentomaxillofac Radiol. 2010;39(3):127-39. doi:10.1259/dmfr/30943934.

Chrcanovic BR, Gomez RS. Glandular odontogenic cyst: An updated analysis of 169 cases reported in the literature. Oral Dis. 2018;24(5):717-24. doi:10.1111/odi.12719.

Kaplan I, Gal G, Anavi Y, Manor R, Calderon S. Glandular odontogenic cyst: Treatment and recurrence. J Oral Maxillofac Surg. 2005;63(4):435-41. doi:10.1016/j.joms.2004.08.007.

Mascitti M, Santarelli A, Sabatucci A, Procaccini M, Lo Muzio L, Zizzi A, et al. Glandular odontogenic cyst: review of literature and report of a new case with cytokeratin-19 expression. Open Dent J. 2014;8:1-12. doi: 10.2174/1874210601408010001.

Figueiredo NR, Dinkar AD, Khorate MM. Glandular odontogenic cyst of the maxilla: a case report and literature review. Pan Afr Med J. 2016;25:116. doi: 10.11604/pamj.2016.25.116.10879.

Noffke C, Raubenheimer EJ. The glandular odontogenic cyst: Clinical and radiological features; review of the literature and report of nine cases. Dentomaxillofac Radiol. 2002;31(6):333-8. doi:10.1038/sj.dmfr.4600730.

Manor R, Anavi Y, Kaplan I, Calderon S. Radiological features of glandular odontogenic cyst. Dentomaxillofac Radiol. 2003;32(2):73-9. doi:10.1259/dmfr/22912856.

Ide F, Shimoyama T, Horie N. Glandular odontogenic cyst with hyaline bodies: an unusual dentigerous presentation. J Oral Pathol Med. 1996;25(7):401-4. doi: 10.1111/j.1600-0714.1996.tb00286.x.

Qin XN, Li JR, Chen XM, Long X. The glandular odontogenic cyst: Clinicopathologic features and treatment of 14 cases. J Oral Maxillofac Surg. 2005;63(5):694-9. doi:10.1016/j.joms.2004.12.016.

Geist J, Gordon S, Wesley R. Oral pathology quiz: an unusual pericoronal cyst. The diagnosis was glandular odontogenic cyst, although focal areas consistent with dentigerous cyst were seen. J Mich Dent Assoc. 2003;85(12):40, 42-3.

Gorlin RJ. Potentialities of oral epithelium manifest by mandibular dentigerous cysts. Oral Surg Oral Med Oral Pathol. 1957;10(3):271-84. doi: 10.1016/0030-4220(57)90092-0.

More CB, Bhavsar K, Varma S, Adalja CJ. Glandular odontogenic cyst: A diagnostic challenge. Indian J Dent. 2013;4(4):219-23. doi:10.1016/j.ijd.2013.07.011.

Ferreira JCB, Vêncio EF, de Sá RT, Gasperini G. Glandular odontogenic cyst in dentigerous relationship: an uncommon case report. Case Rep Dent. 2019;2019:8647158. doi: 10.1155/2019/8647158.

Boffano P, Cassarino E, Zavattero E, Campisi P, Garzino-Demo P. Surgical treatment of glandular odontogenic cysts. J Craniofac Surg. 2010;21(3):776-80. doi:10.1097/SCS.0b013e3181d7a3e6

de Freitas Silva BS, Yamamoto-Silva FP, Sena-Filho M, Silva Sant'Ana SS, Mariano-Júnior WJ, de Almeida OP, et al. 20-year Follow-up of Recurrent Glandular Odontogenic Cyst Mimicking a Periapical Lesion. J Endod. 2017;43(11):1915-20. doi: 10.1016/j.joen.2017.06.015.

Kaplan I, Anavi Y, Manor R, Sulkes J, Calderon S. The use of molecular markers as an aid in the diagnosis of glandular odontogenic cyst. Oral Oncol. 2005;41(9):895-902. doi:10.1016/j.oraloncology.2005.04.015.

Waldron CA, Koh ML. Central mucoepidermoid carcinoma of the jaws: report of four cases with analysis of the literature and discussion of the relationship to mucoepidermoid, sialodontogenic, and glandular odontogenic cysts. J Oral Maxillofac Surg. 1990;48(8):871-7. doi: 10.1016/0278-2391(90)90349-7.

Pires FR, Chen SY, da Cruz Perez DE, de Almeida OP, Kowalski LP. Cytokeratin expression in central mucoepidermoid carcinoma and glandular odontogenic cyst. Oral Oncol. 2004;40(5):545-51. doi:10.1016/j.oraloncology.2003.11.007.

Vered M, Allon I, Buchner A, Dayan D. Is maspin immunolocalization a tool to differentiate central low-grade mucoepidermoid carcinoma from glandular odontogenic cyst? Acta Histochem. 2010;112(2):161-8. doi:10.1016/j.acthis.2008.10.006.

Montague L, Neuman A, Kimbler K, Islam NM, Cohen D, Bhattacharyya I. Histologic and immunohistochemical differentiation between glandular odontogenic cysts and cysts with

features of glandular odontogenic cyst. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;116(6):e497. doi:10.1016/j.oooo.2013.09.032.

Koppang HS, Johannessen S, Haugen LK, Haanaes HR, Solheim T, Donath K. Glandular odontogenic cyst (sialo-odontogenic cyst): report of two cases and literature review of 45 previously reported cases. J Oral Pathol Med. 1998;27(9):455-62. doi: 10.1111/j.1600-0714.1998.tb01984.x.

Bhatt V, Monaghan A, Brown AMS, Rippin JW. Does the glandular odontogenic cyst require aggresive management? Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001;92(3):248-9. doi:10.1067/moe.2001.116606.

Cano J, Benito DM, Montáns J, Rodríguez-Vázquez JF, Campo J, Colmenero C. Glandular odontogenic cyst: two high-risk cases treated with conservative approaches. J Craniomaxillofac Surg. 2012;40(5):e131-6. doi: 10.1016/j.jcms.2011.07.005.

Motooka N, Ohba S, Uehara M, Fujita S, Asahina I. A case of glandular odontogenic cyst in the mandible treated with the dredging method. Odontol. 2015;103(1):112-5. doi:10.1007/s10266-013-0143-0.

Stoelinga PJW. The management of aggressive cysts of the jaws. J Maxillofac Oral Surg. 2012;11(1):2-12. doi:10.1007/s12663-012-0347-9.

Ficarra G, Chou L, Panzoni E. Glandular odontogenic cyst (sialo-odontogenic cyst). A case report. Int J Oral Maxillofac Surg. 1990;19(6):331-3. doi: 10.1016/s0901-5027(05)80074-8.

Akkaş İ, Toptaş O, Özan F, Yılmaz F. Bilateral glandular odontogenic cyst of mandible: a rare occurrence. J Maxillofac Oral Surg. 2015;14(Suppl 1):443-7. doi: 10.1007/s12663-014-0668-y.

Hussain K, Edmondson HD, Browne RM. Glandular odontogenic cysts. Diagnosis and treatment. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995;79(5):593-602. doi: 10.1016/s1079-2104(05)80101-5.

Thor A, Warfvinge G, Fernandes R. The course of a long-standing glandular odontogenic cyst: marginal resection and reconstruction with particulated bone graft, platelet-rich plasma, and additional vertical alveolar distraction. J Oral Maxillofac Surg. 2006;64(7):1121-8. doi:10.1016/j.joms.2006.03.042.

Kaplan I, Anavi Y, Hirshberg A. Glandular odontogenic cyst: A challenge in diagnosis and treatment. Oral Dis. 2008;14(7):575-81. doi:10.1111/j.1601-0825.2007.01428.x.



About The Authors

Varvara-Velika Rogova
Medical University of Varna

Department of Oral Surgery, Faculty of Dental Medicine

Tihomir Georgiev
Medical University of Varna

Department of Oral Surgery, Faculty of Dental Medicine

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