In this work, the series of new 4-phenyl-5-4-(R)-phenoxymethyl-1,2,4-triazole-3-ylthio-1-(R1)-acetophenones have been synthesized by alkylation of correspondent 4-phenyl-5-phenoxymethyl-3-mercapto-1,2,4-triazoles (4H) with the α-chloroacetophenones. The structure of the synthesized substances has been proven by NMR spectra. High possibility of anti-ulcer and anti-helicobacter activity was determined by the PASS program. Molecular docking and anti-ulcer screening of new 1,2,4-triazole(4H) derivatives on the acute alcohol-prednisolone model NSAID-induced ulcers in rats has been performed.
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