MMP2 -1306C>T polymorphism in patients with COPD

Tanya Tacheva; Dimo Dimov; Pavlina Chelenkova; Rumena Petkova; Stoyan Chakarov; Tatyana Vlaykova

doi:10.14748/ssp.v1i1.1413

MMP2 -1306C>T polymorphism in patients with COPD

Tanya Tacheva, Dimo Dimov, Pavlina Chelenkova, Rumena Petkova, Stoyan Chakarov, Tatyana Vlaykova

Abstract

The remodeling of the bronchial walls is an important process of the pathophysiology of COPD as the matrix metalloproteinase-2 (MMP-2) is shown to play an important role in this process. The aim of the current study was to elucidate the possible role of MMP2 -1306C>T promoter polymorphism as risk factor of COPD. We genotyped by PCR-RFLP 84 patients with COPD and 71 control individuals. The genotype, but not allele distribution, differed between COPD patients and controls (p=0.021 and 0.602, respectively). Carriers of the variant T allele (CT+TT) tended to have 1.64-fold higher risk for COPD (95% CI: 0.82-3.26, p=0.164) than those with CC genotype, as that risk was significant in the subset of older than 65 years individuals (OR=4.24, 95% CI:1.31-13.57, p=0.019). The risk for COPD of T carriers (CT+TT) was significant and even higher in the subset of older individuals (more than 65 years) and in those without diabetes as a co-morbidity. Patients with T genotypes had later onset of the disease (64.1±7.1 years) than those with CC genotype (59.7±9.5 years, p=0.045). In conclusion, our results suggest that the T genotypes of MMP2 -1306C>T SNP may determine a risk for COPD especially in advanced age.

Keywords

COPD, matrix metalloproteinases, polymorphism

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DOI: http://dx.doi.org/10.14748/ssp.v1i1.1413