Vitamin D is an essential steroid hormone. The role of Vitamin D in mineral metabolism and skeletal health as related to calcium homeostasis is well established. In addition to this role, vitamin D has been recently accepted also as immune modulator and thus it could be possibly implicated in the pathogenesis of system-ic lupus erythematosus (SLE). This review focuses on the question: „Is vitamin D deficiency involved in the pathogenesis of SLE or is it a consequence of the disease state?” and comments the known positive effects of vitamin D supplementation on SLE disease activity.
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