Oxidative stress is a key factor for induction of chronic inflammation by activation of variety of transcription factors and proinflammatory cytokines, which in turn could mediate different chronic pathological conditions. In the present study Morus nigra heartwood ethanol infusion was applied to oxidatively-stimulated macrophage cells with the aim to investigate the effect of the plant on the expression of genes involved in proinflammatory response. The infusion markedly reduced the mRNA levels of nuclear factor kB (NF-kB), tumor necrosis factor alpha (TNF-α) and interleukin-1β (IL-1β) in a concentration dependent manner. These results are a new contribution to the knowledge about the therapeutic potential of the mulberry tree, especially about its poorly examined heartwood.
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