In this work, we have described the method of 3-benzyl-8-methylxanthinyl-7-acetohydrazide synthesis and studied its reaction with different aldehydes and ketones in acidic medium. As result, we obtained a series of novel ylidenhydrazides of 3-benzyl-8-methylxanthinyl-7-acetic acid. The structure of the synthesized substances was proved by IR and NMR spectra and elemental analysis and their individuality was confirmed by thin-layer chromatography.
Saini MS, Kumar A, Dwivedi J, Singh R. A Review: Biological significances of heterocyclic compounds. Int J Pharm Sci Res. 2013;3(4):66-77.
Joule JA, Mills K. Heterocycles in Nature. In: Heterocyclic Chemistry at a Glance. Chichester: John Wiley & Sons, Ltd.; 2010. p. 158-166.
Joule JA, Mills K Heterocycles in Medicine. In: Heterocyclic Chemistry at a Glance. Chichester: John Wiley & Sons, Ltd.; 2010, p. 167-179.
Murray RK, Granner DK, Mayes PA, Rodwell VW. Harper`s Illustrated Biochemistry. 26th ed. India: LANGE medical books; 2006.
Satyanarayana U, Chakrapani U. Biochemistry. 3rd ed. Kolkata: Books and Allied; 2006.
Mohamed T, Osman W, Tin G, Rao PN. Selective inhibition of human acetylcholinesterase by xanthine derivatives: In vitro inhibition and molecular modeling investigations. Bioorg Med Chem Lett. 2013; 23(15):4336-41. doi: 10.1016/j. bmcl.2013.05.092
Mak G, Hanania NA. New bronchodilators. Curr Opin Pharmacol. 2012; 12(3): 238-45. doi: 10.1016/j. coph.2012.02.019
Song B, Xiao T, Xiaolu Q. Design and synthesis of 8-substituted benzamido-phenylxanthine derivatives as MAO-B inhibitors. Bioorg Med Chem Lett. 2012;22(4):1739-42. doi: 10.1016/j.bmcl.2011.12.094
Romanenko NI, Nazarenko, MV, Ivanchenko DG, Pakhomova OO, Sharapova TA. The study of reactions of 7-substituted 8-hydrazino-3-methylxanthine with β-dicarbonyl compounds. Aktualni pytannia farmatsevtychnoi i medychnoi nauky ta praktyky. 2015;2(18):4-8. doi: 10.14739/2409-2932.2015.2.45125
Ivanchenko DG. Synthesis, physical-chemical and biological properties of 1,8-disubstituted of theobromine. V. 8-Benzylidenhydrazino- 1-p-methylbenzyltheobromines. Zaporozhskij medicinskij zhurnal. 2015;5(92):89-92. doi: 10.14739/2310-1210.2015.5.53768
Ivanchenko DH, Romanenko MI, Sharapova TA, Aleksandrova KV, Kamyshny AM, Polishchuk NM. Synthesis and antibacterial properties of 8-beznylidenhydrazine-1-propyltheobromines. Aktualni pytannia farmatsevtychnoi i medychnoi nauky ta praktyky. 2015;1(17):51-5.
Levich SV, Shkoda AS, Aleksandrova KV. Synthesis and physicochemical properties of S-substituted derivatives of 3-benzyl-8-methyl-7-[(4-phenyl- 5-thio-4H-1,2,4-triazolyl-3)-methyl]xanthine. Aktualni pytannia farmatsevtychnoi i medychnoi nauky ta praktyky. 2013;1(11):54-8.
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