The final goal of the present investigation is the development of new cytostatic agents belonging to the class of the non-conventional platinum-based anticancer drugs. Such compounds, more or less, differ in their structure and mechanism of action from the parent drug cisplatin, but, at the same time, retain their activity against cisplatin-resistant tumors.
Main results, materials and methods: In continuation of our systematic studies of N-3-pyridinylmethane-sulfonamide (PMSA) and its Pt(II) and Pd(II) complexes, here we report the synthesis and physical characterization at experimental and theoretical level of two novel complexes of Pt(II): cis- (1) and trans-[Pt(PMSA)2(NO3)2] (2). The structure of 1 has been solved by single crystal X-ray diffraction: orthorhombic; Pbca; a = 19.8017(6), b = 9.8042(3), c = 24.0279(8); Z = 8; Rint = 0.044, and compared with the quantum-chemically calculated one (HF ab initio level with 6-31++G(d,p)/LANL08-ECP basis sets). The analysis of the X-ray powder pattern of 2 revealed the following unit cell parameters: triclinic; P1 ; a = 16.149(6), b = 19.744(7), c = 7.486(4), α = 96.00(4), β = 94.66(2), γ = 93.55(9); Ζ = 2. The complexes have also been characterized by IR and NMR (1H, 13C and 195Pt) spectroscopy.
Conclusion: A good agreement between the experimental and calculated physical properties of complexes 1 and 2 has been achieved. Their cytotoxic activity evaluation is now in progress.
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