Abstract
Augmentin is a penicillin antibiotic. Penicillin was discovered by Alexander Fleming in 1928. Penicillins are water soluble drugs. The mechanism of incorporation of water soluble drugs represents a passive transport (water diffusion). It is performed in the aqueous pores of the membrane. Pores are disposed in the epithelial lining of the bowel, bladder, and between the epithelial cells of the capillaries. The main route of administration is injecting intramuscularly or intravenously (parenteral). Augmentin is a broad spectrum antibiotic compound comprising amoxycillin and clavulanic acid of (β-lactam antibiotics) in a ratio of 4:1. It is used in skin and soft tissue infections including dental infections (after extraction of molars), intra-abdominal (abdominal) and pelvic sepsis and respiratory infections, infections affecting the lungs (bronchitis, pneumonia), tonsils (tonsillitis), sinuses (sinusitis), ears (otitis media), genitourinary system, bones, joints. Available in tablets 375-1000mg, suspensions 60-100ml, dry bottles 600 and 1200 mg. It is used in adults and children over 12 years. It is orally administered at a dose of 375 to 625mg/8h for 5-10 days. In severe cases it is injected intravenously at a dose of 1.2-2.4 g every 6 or 8 hours. Penicillins are remarkably nontoxic medi-cines. This is due to their mechanism of action. This is the reason why penicillins are authorized for use dur-ing pregnancy because they are harmless to the fetus.
Keywords
augmentin, transport, mechanism of action, penicillins