Intravenous lipid emulsion infusion in acute intoxication with fenitrothion

Petko Marinov; Dobri Ivanov; Snezha Zlateva; Simeonka Dimitrova; Gabriela Kehayova; Maya Radeva; Stanila Stoeva

doi:10.14748/ssp.v1i1.5108

Intravenous lipid emulsion infusion in acute intoxication with fenitrothion

Petko Marinov, Dobri Ivanov, Snezha Zlateva, Simeonka Dimitrova, Gabriela Kehayova, Maya Radeva, Stanila Stoeva

Abstract

Acute intoxications with organophosphorus pesticides (OPs) are a challenge for the clinical toxicology, because they are common, severe and with high lethality. Most OPs are lipophilic. In recent years, intravenous lipid emulsion (ILE) has been successfully used to treat acute poisoning with lipophilic xenobiotics. A clinical case of a 64-year-old male hospitalized after oral intake of 50 ml of fenitrothion is reported. He had been hospitalized with tachypnea and depressed consciousness - 8 by Glasgow coma scale (GCS). Standardized for this type of intoxication treatment was initiated. On the 3rd hour treatment with Intralipid 20% was started, with a bolus dose of 1.5 ml/kg followed by infusion at a rate of 0.25 ml/kg/min to a total dose of 1000 ml. At the 16th hour consciousness was restored to GCS-15. In severe FTO intoxications ILE can be used as an additional method of controlling cardiotoxic and neurotoxic effects.

Keywords

Fenitrothion; Organophosphorus Pesticides, OPs; Intravenous Lipid Emulsion, ILE; Acute Intoxications

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DOI: http://dx.doi.org/10.14748/ssp.v1i1.5108