Principles of Cell Biology (1st English edition, to hopefully be released December 2017) provides students and teachers with an accessible approach to state-of-the-science (SoS)-based fundamental concepts of cell biology. The textbook is written in-depth and is desirable to be read in-depth if the reader wants to get in-depth information and knowledge about cellular MSF and their importance for the understanding of DPT. Principles of Cell Biology is a didactic shift from the traditional focus on details towards an integrative, translational, bench-to-bedside (BtB) view of cell biology. I hope it will be useful for inquisitive students, lecturers, PhDs and MDs, here in Bulgaria as well as globally.