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Prevalence of Human Papillomavirus type 16 IgG antibodies in people who have visited the cabinet for sexually transmitted diseases

Polya Makaveeva, Aygulya Akisheva, Nina Ivanova, Milena Karcheva, Hristina Haydudova


Introduction: High-Risk Human Papillomavirus (HPV) genotypes 16, 18, 31, 33 are oncogenic types that are connected to the development of cervical cancer in 80-90% of the cases. They are also etiolog­ically connected to anorectal cancer (40-90%) and oropharyngeal cancer (30-40%) in men and wom­en. HPV16 is the most common type in Bulgaria. One of the risk factors associated with the acquisi­tion of genital HPV infection is the presence of other sexually transmitted diseases (STDs). The aim of the study is to determine the distribution of specific Immunoglobulin G antibodies (IgG) of HPV16 in people who have visited the Cabinet for STDs in University hospital `Dr. Georgi Stranski`, Pleven.

Materials and Methods: A seroepidemiological study of 25 people who have visited the Cabinet for sexually transmitted diseases at the Department of Dermatology and Venereology at University hos­pital, Pleven has been conducted for a one month period. HPV16 L1-capsides (HPV16L1) IgG anti­body, Enzyme-linked immunosorbent assay (ELISA) kit, CUSABIO® has been applied. Twenty-five se­rum samples from people from 17 to 55-years-old have been analyzed. Three (12%) of them were male and 22 (88%) were female.

Results: The results show that 18 (72%) of the analyzed are seropositive. Women are predominant - 16 (80%), compared to men - 9 (20%). Of all the seropositive 10 (56%) also have concurrent sexual­ly transmitted diseases - syphilis (n=4), chlamydiasis (n=2), human immunodeficiency virus (HIV) (n=3), condylomata acuminata (n=1).

Conclusion: The discovery of seropositive people to oncogenic types of HPV as well as the presence of other STDs is a good reason for additional screening test to be conducted and prophylactic and ade­quate therapeutic measures to be taken.


HPV type 16 IgG STIs



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