Introduction: High-Risk Human Papillomavirus (HPV) genotypes 16, 18, 31, 33 are oncogenic types that are connected to the development of cervical cancer in 80-90% of the cases. They are also etiologically connected to anorectal cancer (40-90%) and oropharyngeal cancer (30-40%) in men and women. HPV16 is the most common type in Bulgaria. One of the risk factors associated with the acquisition of genital HPV infection is the presence of other sexually transmitted diseases (STDs). The aim of the study is to determine the distribution of specific Immunoglobulin G antibodies (IgG) of HPV16 in people who have visited the Cabinet for STDs in University hospital `Dr. Georgi Stranski`, Pleven.
Materials and Methods: A seroepidemiological study of 25 people who have visited the Cabinet for sexually transmitted diseases at the Department of Dermatology and Venereology at University hospital, Pleven has been conducted for a one month period. HPV16 L1-capsides (HPV16L1) IgG antibody, Enzyme-linked immunosorbent assay (ELISA) kit, CUSABIO® has been applied. Twenty-five serum samples from people from 17 to 55-years-old have been analyzed. Three (12%) of them were male and 22 (88%) were female.
Results: The results show that 18 (72%) of the analyzed are seropositive. Women are predominant - 16 (80%), compared to men - 9 (20%). Of all the seropositive 10 (56%) also have concurrent sexually transmitted diseases - syphilis (n=4), chlamydiasis (n=2), human immunodeficiency virus (HIV) (n=3), condylomata acuminata (n=1).
Conclusion: The discovery of seropositive people to oncogenic types of HPV as well as the presence of other STDs is a good reason for additional screening test to be conducted and prophylactic and adequate therapeutic measures to be taken.
