Scientific Online Resource System

Varna Medical Forum

Osteoporosis and oral health: a review

Ralitsa Yotsova

Abstract

Introduction: Osteoporosis is a multifactorial metabolic disease characterized by reduced skeletal mass and impaired bone microarchitecture, leading to increased susceptibility to fractures. It mainly occurs in middle-aged and elderly individuals and usually proceeds unnoticed until the first bone fracture. This review aims to clarify the relationship between osteoporosis and oral health, identify the risks for these patients during dental treatment, and highlight the need for a multidisciplinary approach between dentists and healthcare providers.

Materials and Methods: An electronic search was performed in Web of Science, Scopus, PubMed, and Google Scholar using the following keywords: osteoporosis, dentistry, oral health, bisphosphonates, periodontal health, and tooth extraction. After selection and analysis of the obtained data, this review included 46 articles.

Results and Discussion: There is a dynamic relationship between osteoporosis and oral health. On the one hand, the pathophysiological processes in osteoporosis have a negative impact on periodontal health and jawbone density and are associated with an increased risk of tooth loss. On the other hand, drug treatment for osteoporosis, including hormone replacement therapy and antiresorptive agents, carries significant risks when performing invasive dental procedures.

Conclusion: The multifactorial nature of the relationship between osteoporosis and dental health requires a multidisciplinary approach, including close collaboration between dentists and specialists managing the systemic disease. Professional oral care is a key prerequisite for treatment success and for limiting the risks of future complications.


Keywords

osteoporosis; dentistry; oral health; bisphosphonates; periodontal health; tooth extraction

Full Text


References

Cummings SR, Melton LJ. Epidemiology and outcomes of osteoporotic fractures. Lancet. 2002 May 18;359(9319):1761–7. doi: 10.1016/S0140-6736(02)08657-9.

Azuma K, Adachi Y, Hayashi H, Kubo KY. Chronic psychological stress as a risk factor of osteoporosis. J UOEH. 2015 Dec;37(4):245–53. doi: 10.7888/juoeh.37.245.

Crandall CJ, Larson JC, LaCroix AZ, Robbins JA, Wactawski-Wende J, Johnson KC, et al. Risk of subsequent fractures in postmenopausal women after nontraumatic vs traumatic fractures. JAMA Intern Med. 2021 Aug;181(8):1055–63. doi: 10.1001/jamainternmed.2021.2617.

Anil S, Preethanath RS, AlMoharib HS, Kamath KP, Anand PS. Impact of osteoporosis and its treatment on oral health. Am J Med Sci. 2013 Nov;346(5):396–401. doi: 10.1097/MAJ.0b013e31828983da.

Raisz LG. Pathogenesis of osteoporosis: concepts, conflicts, and prospects. J Clin Invest. 2005 Dec;115(12):3318–25. doi: 10.1172/JCI27071.

Sharma N, Reche A. Unraveling the relationship between osteoporosis, treatment modalities, and oral health: a comprehensive review. Cureus. 2023 Nov;15(11):e49399. doi: 10.7759/cureus.49399.

Xiao PL, Cui AY, Hsu CJ, Peng R, Jiang N, Xu XH, et al. Global, regional prevalence, and risk factors of osteoporosis according to the World Health Organization diagnostic criteria: a systematic review and meta-analysis. Osteoporos Int. 2022 Oct;33(10):2137–53. doi: 10.1007/s00198-022-06454-3.

International Osteoporosis Foundation: Epidemiology. 2023 [cited 2023 Nov 14]. Available from: https://www.osteoporosis.foundation/health-professionals/about-osteoporosis/epidemiology.

Dervis E. Oral implications of osteoporosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005 Sep;100(3):349–56. doi: 10.1016/j.tripleo.2005.04.010.

Erdogan O, Incki KK, Benlidayi ME, Seydaoglu G, Kelekci S. Dental and radiographic findings as predictors of osteoporosis in postmenopausal women. Geriatr Gerontol Int. 2009 Jun;9(2):155–64. doi: 10.1111/j.1447-0594.2009.00518.x.

Moedano DE, Irigoyen ME, Borges-Yáñez A, Flores-Sánchez I, Rotter RC. Osteoporosis, the risk of vertebral fracture, and periodontal disease in an elderly group in Mexico City. Gerodontology. 2011 Mar;28(1):19–27. doi: 10.1111/j.1741-2358.2009.00342.x.

Yoshihara A, Seida Y, Hanada N, Nakashima K, Miyazaki H. The relationship between bone mineral density and the number of remaining teeth in community-dwelling older adults. J Oral Rehabil. 2005 Oct;32(10):735–40. doi: 10.1111/j.1365-2842.2005.01491.x.

Tezal M, Wactawski-Wende J, Grossi SG, Ho AW, Dunford R, Genco RJ. The relationship between bone mineral density and periodontitis in postmenopausal women. J Periodontol. 2000 Sep;71(9):1492–8. doi: 10.1902/jop.2000.71.9.1492

Wactawski-Wende J, Hausmann E, Hovey K, Trevisan M, Grossi S, Genco RJ. The association between osteoporosis and alveolar crestal height in postmenopausal women. J Periodontol. 2005 Nov;76(Suppl 11):2116–24. doi: 10.1902/jop.2005.76.11-S.2116.

Gerova-Vatsova T. Periodontal splinting–an adjunct to periodontal therapy. Scripta Sci Med Dentis. 2020;6(1):7–12. doi: 10.14748/ssmd.v6i1.6682.

Gerova-Vatsova T. Treatment approach to generalized severe periodontitis with the potential for additional tooth loss: a case report. Cureus. 2024 Nov;16(11):e73336. doi: 10.7759/cureus.73336.

Yu B, Wang CY. Osteoporosis and periodontal diseases—An update on their association and mechanistic links. Periodontol 2000. 2022 Jun;89(1):99–113. doi: 10.1111/prd.12422.

Kuo LC, Polson AM, Kang T. Associations between periodontal diseases and systemic diseases: a review of the inter-relationships and interactions with diabetes, respiratory diseases, cardiovascular diseases, and osteoporosis. Public Health. 2008 Apr;122(4):417–33. doi: 10.1016/j.puhe.2007.07.004.

Jabbar S, Drury J, Fordham J, Datta HK, Francis RM, Tuck SP. Plasma vitamin D and cytokines in periodontal disease and postmenopausal osteoporosis. J Periodontal Res. 2011 Feb;46(1):97–104. doi: 10.1111/j.1600-0765.2010.01317.x.

Bonnet C, Rabbani R, Moffatt MEK, Kelekis-Cholakis A, Schroth RJ. The relation between periodontal disease and vitamin D. J Can Dent Assoc. 2019 Mar;84:j4.

Wang CJ, McCauley LK. Osteoporosis and periodontitis. Curr Osteoporos Rep. 2016 Dec;14(6):284–91. doi: 10.1007/s11914-016-0330-3.

Choi JK, Kim YT, Kweon HI, Park EC, Choi SH, Lee JH. Effect of periodontitis on the development of osteoporosis: results from a nationwide population-based cohort study (2003–2013). BMC Womens Health. 2017 Sep;17(1):77. doi: 10.1186/s12905-017-0440-9.

Qi J, Chen J, Pang Y, Guo Y, Chen G, Liu Y, et al. Association between periodontal disease and osteoporosis in postmenopausal women: A systematic review and meta-analysis. Heliyon. 2023 Oct;9(11):e20922. doi: 10.1016/j.heliyon.2023.e20922.

Al-Qahtani F, Alqhtani N, Divakar DD, Alkhtani F, Alqarawi FK. Levels of whole salivary advanced glycation end products and interleukin-17 and peri-implant clinical and radiographic status in patients with osteoporosis at 6-years' follow-up. BMC Oral Health. 2022 Nov;22(1):526. doi: 10.1186/s12903-022-02591-7.

Wagner F, Schuder K, Hof M, Heuberer S, Seemann R, Dvorak G. Does osteoporosis influence the marginal peri-implant bone level in female patients? A cross-sectional study in a matched collective. Clin Implant Dent Relat Res. 2017 Aug;19(4):616–23. doi: 10.1111/cid.12493.

Al-Fakeh H, Sharhan HM, Ziyad TA, Abdulghani EA, Al-Moraissi E, Al-Sosowa AA, et al. Three-dimensional radiographic assessment of bone changes around posterior dental implants at native bone sites in Gansu Province, Northwest China: A retrospective cohort study. J Stomatol Oral Maxillofac Surg. 2022 Sep;123(4):e186–91. doi: 10.1016/j.jormas.2022.04.005.

Temmerman A, Rasmusson L, Kübler A, Thor A, Merheb J, Quirynen M. A prospective, controlled, multicenter study to evaluate the clinical outcome of implant treatment in women with osteoporosis/osteopenia: 5-year results. J Dent Res. 2019 Jan;98(1):84–90. doi: 10.1177/0022034518798804.

Holahan CM, Wiens JL, Weaver A, Assad D, Koka S. Relationship between systemic bone mineral density and local bone quality as effectors of dental implant survival. Clin Implant Dent Relat Res. 2011 Mar;13(1):29–33. doi: 10.1111/j.1708-8208.2009.00206.x.

Stach RM, Kohles SS. A meta-analysis examining the clinical survivability of machined-surfaced and osseotite implants in poor-quality bone. Implant Dent. 2003;12(1):87–96. doi: 10.1097/01.id.0000042507.37401.6f.

Liu F, Wang X, He Y, Han R, Wang T, Guo Y. Jaw osteoporosis: Challenges to oral health and emerging perspectives of treatment. Biomed Pharmacother. 2024 Aug;177:116995. doi: 10.1016/j.biopha.2024.116995.

Só BB, Silveira FM, Llantada GS, Jardim LC, Calcagnotto T, Martins MAT, et al. Effects of osteoporosis on alveolar bone repair after tooth extraction: A systematic review of preclinical studies. Arch Oral Biol. 2021 May;125:105054. doi: 10.1016/j.archoralbio.2021.105054.

Arioka M, Zhang X, Li Z, Tulu US, Liu Y, Wang L, et al. Osteoporotic changes in the periodontium impair alveolar bone healing. J Dent Res. 2019 Apr;98(4):450–58. doi: 10.1177/0022034518818456.

Chen CH, Wang L, Serdar Tulu U, Arioka M, Moghim MM, Salmon B, et al. An osteopenic/osteoporotic phenotype delays alveolar bone repair. Bone. 2018 Jul;112:212–19. doi: 10.1016/j.bone.2018.04.019.

Taguchi A, Ikegami S, Tokida R, Kamimura M, Sakai N, Horiuchi H, et al. Fragility fractures and delayed wound healing after tooth extraction in Japanese older adults. J Bone Miner Metab. 2020 May;38(3):357–62. doi: 10.1007/s00774-019-01063-3.

Taguchi A, Kamimura M, Nakamura Y, Sugino N, Ichinose A, Maezumi H, et al. Delayed wound healing after tooth extraction and self-reported kyphosis in Japanese men and women. Sci Rep. 2016 Nov 16;6:36309. doi: 10.1038/srep36309.

Lobo RA. Hormone-replacement therapy: current thinking. Nat Rev Endocrinol. 2017 Apr;13(4):220–31. doi: 10.1038/nrendo.2016.164.

Wojda SJ, Donahue SW. Parathyroid hormone for bone regeneration. J Orthop Res. 2018 Oct;36(10):2586–94. doi: 10.1002/jor.24075. Epub 2018 Jul 23.

Heo HA, Park SH, Jeon YS, Pyo SW. Enhancing effect of intermittent parathyroid hormone administration on bone formation after titanium implant placement in an ovariectomized rat maxilla. Implant Dent. 2016 Apr;25(2):227–31. doi: 10.1097/ID.0000000000000352.

Bellido M, Lugo L, Castañeda S, Roman-Blas JA, Rufián-Henares JA, Navarro-Alarcón M, et al. PTH increases jaw mineral density in a rabbit model of osteoporosis. J Dent Res. 2010 Apr;89(4):360–65. doi: 10.1177/0022034510363082.

Sato M, Vahle J, Schmidt A, Westmore M, Smith S, Rowley E, Ma LY. Abnormal bone architecture and biomechanical properties with near-lifetime treatment of rats with PTH. Endocrinology. 2002 Sep;143(9):3230–42. doi: 10.1210/en.2002-220149.

Curi MM, Cossolin GS, Koga DH, Zardetto C, Christianini S, Feher O, et al. Bisphosphonate-related osteonecrosis of the jaws—An initial case series report of treatment combining partial bone resection and autologous platelet-rich plasma. J Oral Maxillofac Surg. 2011;69:2465–72. doi: 10.1016/j.joms.2011.02.078

Ruggiero SL, Dodson TB, Aghaloo T, Carlson ER, Ward BB, Kademani D. American Association of Oral and Maxillofacial Surgeons' position paper on medication-related osteonecrosis of the jaws—2022 update. J Oral Maxillofac Surg. 2022;80:920–43. doi: 10.1016/j.joms.2022.02.008.

Shudo A, Kishimoto H, Takaoka K, Noguchi K. Long-term oral bisphosphonates delay healing after tooth extraction: A single institutional prospective study. Osteoporos Int. 2018;29:2315–21. doi: 10.1007/s00198-018-4621-7.

Watts NB, Grbic JT, Binkley N, Papapoulos S, Butler PW, Yin X, et al. Invasive oral procedures and events in postmenopausal women with osteoporosis treated with denosumab for up to 10 years. J Clin Endocrinol Metab. 2019;104:2443–52. doi: 10.1210/jc.2018-01965.

Lončar Brzak B, Horvat Aleksijević L, Vindiš E, Kordić I, Granić M, Vidović Juras D, Andabak Rogulj A. Osteonecrosis of the jaw. Dent J. 2023;11(1):23. doi: 10.3390/dj11010023.

Kün-Darbois JD, Fauvel F. Medication-related osteonecrosis and osteoradionecrosis of the jaws: Update and current management. Morphologie. 2021;105(349):170–87. doi: 10.1016/j.morpho.2020.11.008.




DOI: http://dx.doi.org/10.14748/vmf.v14i1.10304

Refbacks

Font Size


|