The assessment of the risk profile facilitates the process of identification of patients at high risk at the individual, group, and social levels, which considerably supports and optimizes the process of early prevention, prophylaxis, and efficient management of rampant caries. We focus on two clinical cases with primary dentition and one clinical case with mixed dentition. Parallel to the great number of deciduous and permanent teeth affected by an active tooth decay process in these patients, we establish a clinical manifestation of a generalized form of moderate plaque-induced gingivitis. There is a definite necessity of the performance of complex prophylaxis related to the utilization of the potentials of exogenous fluoride prophylaxis, nutrition, and oral hygiene for the improvement of the oral-dental status.
Abudrya M, Splieth CH, Mourad MS, Santamaría RM. Efficacy of different fluoride therapies on hypersensitive carious lesions in primary teeth. Medicina (Kaunas). 2023;59(11):2042. doi:10.3390/medicina59112042
Alshayeb L, Dashash M. Prevalence and clinical risk factors of dental caries in Syrian children: a cross-sectional study. Sci Rep. 2025;15:10721. doi:10.1038/s41598-025-95534-5.
Asahi Y, Naito K, Kanda H, Niwano K, Takegawa D, Yumoto H, Noiri Y, Hayashi M. Clinical investigation of the inhibitory effects of tooth-coating materials on initial active root caries: a pilot randomized controlled trial. Medicina (Kaunas). 2024;60(1):150. doi:10.3390/medicina60010150.
4. Cheng L, Zhang L, Yue L, Ling J, Fan M, Yang D, Huang Z, Niu Y, Liu J, Zhao J, Li Y, Guo B, Chen Z, Zhou X. Expert consensus on dental caries management. Int J Oral Sci. 2022;14(1):17. doi:10.1038/s41368-022-00167-3.
Georgieva-Dimitrova MT. Case report: the use of universal highly aesthetic nano-hybrid composite for restoration of primary molars. Scr Sci Med Dent. 2019;5(2):50. doi:10.14748/ssmd.v5i2.6266.
Georgieva-Dimitrova M, Dimitrov E. Full oral rehabilitation of a child under general anesthesia: a case report. Scr Sci Med Dent. 2020;6(1):38-43. doi:10.14748/ssmd.v6i1.6653.
González-Gil D, Flores-Fraile J, Vera-Rodríguez V, Martín-Vacas A, López-Marcos J. Comparative meta-analysis of minimally invasive and conventional approaches for caries removal in permanent dentition. Medicina (Kaunas). 2024;60(3):402. doi:10.3390/medicina60030402.
James Y, Nadeem A, Carpenter F. Role of the early detection and prevention of dental caries in children: a systematic review of clinical outcomes. Cureus. 2025;17(6):e85185. doi:10.7759/cureus.85185.
Kazeminia M, Abdi A, Shohaimi S, Jalali R, Vaisi-Raygani A, Salari N, Mohammadi M. Dental caries in primary and permanent teeth in children's worldwide, 1995 to 2019: a systematic review and meta-analysis. Head Face Med. 2020;16:22. doi:10.1186/s13005-020-00237-z.
Lamloum D, Dettori M, La Corte P, Agnoli MR, Cappai A, Viarchi A, Arghittu A, Wolf TG, Castiglia P, Campus G. Oral health survey in Burundi: evaluation of the caries experience in schoolchildren using the DMFT index. Medicina (Kaunas). 2023;59(9):1538. doi:10.3390/medicina59091538.
Li X, Li R, Wang H, Yang Z, Liu Y, Li X, Xue X, Sun S, Wu LA. Global burden of dental caries from 1990 to 2021 and future projections. Int Dent J. 2025;75(5):100904. doi:10.1016/j.identj.2025.100904.
Xu L, Jiang L, Huang Y. Risk management of rampant caries and MDT sequence treatment. Int Dent J. 2025;75(Suppl 1):104564. doi:10.1016/j.identj.2025.104564.
Machiulskiene V, Campus G, Carvalho JC, Dige I, Ekstrand KR, Jablonski-Momeni A, et al. Terminology of dental caries and dental caries management: consensus report of a workshop organized by ORCA and the Cariology Research Group of IADR. Caries Res. 2020;54(1):7-14. doi:10.1159/000503309.
Mineva K, Georgieva M. Influence of water- and fat-soluble vitamins on oral health in adolescence. Scr Sci Med Dent. 2024;10(1):17-22. doi:10.14748/ssmd.v10i1.9172.
Namita, Rai R. Adolescent rampant caries. Contemp Clin Dent. 2012;3(Suppl 1):S122-S124. doi:10.4103/0976-237X.95122.
Petrauskienė S, Saldūnaitė-Mikučionienė K, Narbutaitė J. Survival analysis of glass ionomer cement and resin-based sealant retention: a 10-year follow-up study. Medicina (Kaunas). 2024;60(5):756. doi:10.3390/medicina60050756.
Schmoeckel J, Gorseta K, Splieth CH, Juric H. How to intervene in the caries process: early childhood caries—a systematic review. Caries Res. 2020;54(2):102-112. doi:10.1159/000504335.
Schmoeckel J. Updates on caries management in the primary and permanent dentition. Medicina (Kaunas). 2025;61(2):316. doi:10.3390/medicina61020316.
Splieth CH, Banerjee A, Bottenberg P, Breschi L, Campus G, Ekstrand KR, et al. How to intervene in the caries process in children: a joint ORCA and EFCD expert Delphi consensus statement. Caries Res. 2020;54(4):297-305. doi:10.1159/000507692.
Wolf TG, Campus G. Cost-effectiveness of treatment decisions for early childhood caries in infants and toddlers: a systematic review. Medicina (Kaunas). 2023;59(10):1865. doi:10.3390/medicina59101865.
Wong HM. Childhood caries management. Int J Environ Res Public Health. 2022;19(14):8527. doi:10.3390/ijerph19148527.
