Introduction: Hyperglycemia during acute coronary syndrome (ACS) in patients without known diabetes is common and is considered `stress hyperglycemia`. On the other hand, it could be the first indication for previous unrecognized glycemic abnormality.
Aim: To search for correlation between blood glucose (BG) at acute admission due to ACS and glycemic parameters during oral glucose tolerance test (OGTT). Materials and methods: A standard OGTT 3-10 days after hospital discharge was applied in 96 patients without history of glucose abnormalities who underwent coronary angiography (CA) percutaneous coronary intervention (PCI). Glucose tolerance was defined according to WHO-2006 criteria for fasting plasma glucose (FPG) and 2-hour-plasma glucose (2-h-PG). The BG at acute admission in 39 ACS patients was analyzed.
Results: We found impaired glucose metabolism in 64.58% and 2-hour-hyperglycemia (≥7,8 mmol/L) in 52,1% of study participants after the OGTT. Mean BG at acute admission in subjects with newlydiagnosed type 2 diabetes mellitus (nT2DM) was 9,551,93 mmol/L. It was significantly higher com
Чернева, Ж., Денчев, С., Чернева, Р. Хипергликемични показатели при хоспитализацията за диагноза на нарушенията в глюкозния метаболизъм сред остър коронарен синдром // Ендокринология, 2012, 16 (4), с. 193-204.
Bartnik M, Malmberg K, Norhammar A, Tenerz A, Ohrvik J, Rydén L. Newly detected abnormal glucose tolerance: an important predictor of long-term outcome after myocardial infarction. Eur Heart J. 2004; 25: 1990–1997.
Bartnik M, Ryden L, Ferrari R, Malmberg K, Pyorala K, Simoons M et al. The prevalence of abnormal glucose regulation in patients with coronary artery disease across Europe: the Euro Heart Survey on diabetes and the heart. Eur Heart J. 2004; 25 (21): 1880 –1890.
Bronisz A, Kozinski M, Magielski P, Fabiszak T, Bronisz M, Swiatkiewicz I et al. Stress hyperglycaemia in patients with first myocardial infarction. Int J Clin Pract. 2012; 66(6):592-601.
Bryniarski L, Terlecki M, Bednarek A, Kocowska M, Szynal S, Kawecka-Jaszcz K. The effects of acute hyperglycaemia on the in-hospital and long-term prognosis in patients with an acute coronary syndrome--a pilot study. Kardiol Pol. 2011; 69(8):774-81.
Planer D, Witzenbichler B, Guagliumi G, Peruga JZ, Brodie BR, Xu K, et al. Impact of hyperglycemia in patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention: The HORIZONS-AMI trial. Int J Cardiol. 2013; 167 (6): 2572-9.
Pinto DS, Kirtane AJ, Pride YB, Murphy SA, Sabatine MS, Cannon CP et al. CLARITYTIMI 28 Investigators. Association of blood glucose with angiographic and clinical outcomes among patients with ST-segment elevation myocardial infarction (from the CLARITY-TIMI-28 study). Am J Cardiol. 2008; 101:303–307.
Goyal A, Mehta SR, Díaz R, Gerstein HC, Afzal R, Xavier D et al. Differential clinical outcomes associated with hypoglycemia and hyperglycemia in acute myocardial infarction. Circulation. 2009; 120:2429–2437.
Conaway DG, O‘Keefe JH, Reid KJ. Frequency of undiagnosed diabetes mellitus in patients with acute coronary syndrome. Am J Cardiol. 2005;96:363–5
Hu DY, Pan CY, Yu JM. The relationship between coronary artery disease and abnormal glucose regulation in China: the China Heart Survey. Eur Heart J. 2006; 27 (21): 2573–2579.
Ishihara M, Inoue I, Kawagoe T, Shimatani Y, Kurisu S, Hata T, et al. Is admission hyperglycaemia in non-diabetic patients with acute myocardial infarction a surrogate for previously undiagnosed abnormal glucose tolerance? EurHeart J. 2006;27:2413–2419.
Karetnikova V, Gruzdeva O, Uchasova E, Osokina A, Barbarash O. Glucose levels as a prognostic marker in patients with STsegment elevation myocardial infarction: a case-control study. BMC Endocr Disord.2016; 16(1):31.
Meloni L, Montisci R, Sau L, Boi A, Marini A, Ruscazio M. Admission hyperglycemia in acute myocardial infarction: possible role in unveiling patients with previously undiagnosed diabetes mellitus. J Cardiovasc Med (Hagerstown). 2013; 14(11):821-6.
Okosieme OE, Peter R, Usman M, Bolusani H, Suruliram P, George L et al. Can admission and fasting glucose reliably identify undiagnosed diabetes in patients with acute coronary syndrome? Diabetes Care. 2008; 31(10):1955-9.
Ritsinger V, Tanoglidi E, Malmberg K, Nasman P, Ryden L, Tenerz A et al. Sustained prognostic implications of newly detected glucose abnormalities in patients with acute myocardial infarction: long-term follow-up of the Glucose Tolerance in Patients with Acute Myocardial Infarction cohort. Diab Vasc Dis Res. 2015; 12(1):23-32.
Tamita K, Katayama M, Takagi T, Yamamuro A, Kaji S, Yoshikawa J et al. Newly diagnosed glucose intolerance and prognosis after acute myocardial infarction: comparison of post-challenge versus fasting glucose concentrations. Heart. 2012; 98(11):848-54.
Wascher TC, Sourij H, Roth M, Dittrich P. Prevalence of pathological glucose metabolism in patients undergoing elective coronary angiography. Atherosclerosis. 2004; 176 (2):419–421.
Ye Y, Xie H, Zhao X, Zhang S. The oral glucose tolerance test for the diagnosis of diabetes mellitus in patients during acute coronary syndrome hospitalization: a meta-analysis of diagnostic test accuracy. Cardiovasc Diabetol. 2012; 11:155.