Aim: to study the etiological spectrum and antimi- crobial resistance of most frequently isolated infectious agents of enteric infections in patients, hospitalized in the infectious and non-infectious wards of University Hospital `Saint Marina` - Varna for the period July 2016 - February 2017.
Мaterial and methods: a total of 2165 fecal sam- ples were tested for the most important bacterial and viral agents: Salmonella spp., Shigella spp., Y. en- terocolitica, V. cholerae (tested samples, n=2047), E. coli (n=1311), Campylobacter spp. (n=50), C. difficile (n=428), Rotavirus, Norovirus, Adenovirus and As- trovirus (n=560).
Results: The positive fecal samples were 19.9% (n=430). Viral etiology was identified in 66.7% of all positive samples: Rotavirus, 50%; Norovirus, 7.4%;
Adenovirus, 7%; Astrovirus, 2.3%; Salmonella spp., Shigella spp., EPEC and Campylobacter spp. were de- tected in 10.9%, 1.4%, 1.6% and 1.6% respectively. In the group of 428 samples tested for C. difficile, toxi- genic strains were identified in 17.8% (16.6% (n=64) from the samples, collected from the non-infectious wards (n=385) and respectively - 27.9% (n=12) from these, obtained from patients, hospitalized in the In- fectious wards of the Hospital (n=43). Co-infections were found in 14 patients in the age of 0 - 5 years: Ade- novirus + Astrovirus + Rotavirus + Norovirus; Astro-
virus + C. difficile + S. enteritidis; Rotavirus + Adeno- virus + S. enteritidis, etc. Among Salmonella spp. iso- lates, S. enteritidis (n=29) and S. typhimurium (n=14) were the most common serotypes. The resistance rates of Salmonella spp. isolates to antimicrobial agents is as followes: pefloxacin - 4%; trimethoprim/sulfаmethox- azole - 8.5%; ampicillin - 40%.
Conclusion: The viral pathogens were the most commonly identified etiological agents, with the lead- ing role of Rotavirus in the age of 0 - 5 years, followed by C. difficile and Salmonella spp. Quinolones and tri- methoprim/sulfаmethoxazole are with preserved ac- tivity against Salmonella spp.
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