The osteoporosis is one of the diseases with the big- gest medico-social significance.
The medical experts forecast its significant increase in the future, because of the growing life expectancy in the developed nations. An insufficient use of prophy- laxis is present, wherefore emerges a need of analysis of the possibilities of their more efficient application.
The goal of this review is to summarize the main risk factors of development of osteoporosis and to high- light the most efficient prophylaxis measures in order to curtail it.
It`s never too early to invest in one`s bone health. The prophylaxis of the osteoporosis must begin from childhood through providing the necessary conditions for optimal growth and development of the bone struc- ture. The bone mass, acquired in the maturing phase is a key factor in determining the risk of osteoporosis later in life. The bigger the peak bone mass, acquired while maturing, the lower the risk of bone density loss in the menopause period. That`s why it`s important to lay down the prophylaxis` foundation since childhood and to continue throughout life.
American College of Sports Medicine.
Position stand: Exercise and physical activity for older adults. Med Sci Sports Exerc 1998;30:992-1008.
Bainbridge, К.Е., Sowers, М., Lin, Х., Harlow,
S.D. Risk factors for low bone mineral density and the 6-year rate of bone loss among premenopausal and perimenopausal women. Osteoporos Int. 2004. 15:439.
Baines, М, et al.The association of homocysteine and its determinants MTHFR genotype, folate, vitamin В12 and vitamin В6 with bone mineral density in postmenopausal British women. Bone, Vol. 40, March 2007, рр. 730-36
Blair, S.N., Brodney, S. Effects of physical inactivity and obesity on morbldity and mortality:current evidence and research issues. Med Sci Sports Exerc 1999;31:S646-62.
Blair, S.N., Cheng, У., Holder, J.S. ls physical activity or physical fitness more important
in defining health benefitsi' (discussion S419- 20).Med Sci Sports Exerc 2001;33:S379-99.
Bonaiuti, D., Shea, В., lovine, R., Negrini, S., Roblnson, V., Kemper, Н.С., Wells,
G., Tugwell, Р., Cranney, А. Exercise for
preventing and treating osteoporosis in postmenopausal women. Cochrane Database Syst Rev. 2002.(3).
Brooke-Wavell, К., Jones, P.R., Hardman, А.Е., et al. Commencing, continuing and stopping brisk walking: effects on bone mineral density, quantitative ultrasound of bone and markers of bone metabolism in postmenopausal women. Osteoporos Int. 2001. 12:581.
Cooper, С., Cawley, М., Bhalla, А., et al. Childhood growth, physical activity, and peak bone mass in women. J Bone Miner Res. 1995 10:940.
Cooper, С., Fall, С., Egger, Р., et al. Growth in infancy and bone mass in later life. Ann Rheum Dis. 1997. 56:17.
Duppe, Н., Cooper, С., Gardsell, Р., Johnell, О. The relationship between childhood growth, bone mass, and muscle strength in male and female adolescents. Calcif Tissue Int. 1997. 60:405.
EFFO and NOF. Who are candidates for prevention and treatment for osteoporosisi' Osteoporos Int. 1997. 7:1.
Ensrud, К.Е., Ewing, S.К., Stone, К.L., et al. Intentional and unintentional weight loss increase bone loss and hip fracture risk in older women. J Am Geriatr Soc. 2003.
:1740.
Gjesdal, C.G., et al. Plasma total homocysteine level and bone mineral density. Archives oflnternal Medicine, Vol. 166, January 9, 2006, рр. 88-94
Holick, M.F., et al. Prevalence of vitamin D inadequacy among postmenopausal North American women receiving osteoporosis therapy. Journal of Clinical Endocrinology
and Metabolism, Vol. 90, June 2005, рр.3215-24
Johnell, О. and Kanis, J.A.An estimate of the worldwide prevalence and disabllity associated with osteoporotic fractures.
Osteoporos Int. 2006. 17:1726.
Kanis, J.A. WHO Technical Report, University of Sheffield, UK 2007. 66.
Kanis, J.A, Johnell, О., Oden, А., et al.
Smoking and fracture risk:а meta-analysis. Osteoporos Int. 2005. 16:155.
Karlsson, М. Has exercise an antifracture efficacy in women? Scand J Med Sci Sports. 2004. 14:2.
Koh, J.M., et al. Homocysteine enhances bone resorption Ьу stimulation of osteoclast formation and activity through increased intracellular ROS generation. Journal of Bone and Mineral Research, Vol. 21, July 2006, рр. 1003-11
Law, M.R. and Hackshaw, А.К. (1997) А meta-analysis of cigarette smoking, bone mineral density and risk of hip fracture: recognition of а major effect. BMJ 315:841.
Lee, 1.М., Skerrett, P.J. Physical activity and all-cause mortality: What is the dose response relation? (discussion S493-4). Med
Sci Sports Exerc 2001;33:S459-71. (PubMed)
Ludvigsson, JF, et al. Coeliac disease and the risk of fractures. Aliment. Pharmacol. Ther., Vol. 25, No. 3, February 1, 2007, рр. 273-85
Morris, MS, et al. Relation between homocysteine and B-vitamin status indicators and bone mineral density in older Americans. Bone, Vol. 37, 2005, рр. 234-42
New, S.A. Do vegetarians have а normal bone mass? Osteoporos Int. 2004. 15:679.
Nguyen, T.V., Kelly, P.J., Sambrook, P.N., et al. Lifestyle factors and bone density in the elderly: implications for osteoporosis
prevention. J Bone Miner Res. 1994. 9:1339.
Obermayer-Pietsch ВМ, Bonelli СМ, Walter DE, et al. (2004) Genetic predisposition for adult lactose intolerance and relation to diet, bone density, and bone fractures. J Bone Miner Res 19:42.
Pocock NA, Eisman JA, Hopper JL, et al. (1987) Genetic determinants of bone mass in adults. А twin study. J Clin Invest 80:706.
Rizzoli, R, et al. Risk factors for vitamin D inadequacy among women with osteoporosis: an international epidemiological study. International Journal of Clinical Practice, Vol. 60, August 2006, рр. 1013-19
Seeman Е, Hopper JL, Bach LA, et al. (1989) Reduced bone mass in daughters of women with osteoporosis. N Engl J Med 320:554.
Shea В, Wells G, Cranney А, et al. (2002) Meta-analyses of therapies for
postmenopausal osteoporosis. VII. Meta analysis of calcium supplementation for the prevention of postmenopausal osteoporosis. Endocr Rev 23:552.
Shephard RJ. Absolute versus relative intensity of physical activity in а dose response context. (discussion S419-20).Med Sci Sports Exerc 2001;33:S400-18. (PubMed)
Specker В and Binkley Т (2003) Randomized trial of physical activity and calcium supplementation on bone mineral content in 3- to 5-year-old children. J Bone Miner Res 18:885.
Stazi, AV and Trinti, В. Reproduction, endocrine disorders and celiac disease: Risk factors of osteoporosis. Minerva Med, Vol. 97, No.2, April 2006, рр. 191-203 (article in Italian - English abstract only))
Taylor RS, Brown А, Ebrahim S, et al. Exercise-based rehaЬilitation for patients with coronary heart disease:systematic review and meta-analysis of randomized controlled trials. Ат J Med 2004;116:682-92. (PubMed)
Thijssen JH (2006) Gene polymorphisms involved in the regulation of bone quality. Gynecol Endocrinol 22:131.
Turner СН, Homeostatic control of bone structure: an application of feedback theory. Bone. 1991;12203- 217PubMedArticle
U.S. Department of Health and Human Services. Healthy people 2000: national health promotion and disease prevention objectives. In. Washington: US Department of Health and Human Services; 1991.
Warburton DE, Gledhill N, Quinney А. Musculoskeletal fitness and health. Сап J Appl Physiol 2001;26:217-37. (PubMed)
Warburton DE, Gledhill N, Quinney А. The
effects of changes in musculoskeletal fitness on health. Сап J Appl Physiol 2001;26:161- 216.(PubMed)
Ward KD and Кlesges RC (2001) А meta analysis of the effects of cigarette smoking on bone mineral density. Calcif Tissue Int 68:259.
