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Varna Medical Forum

Expression of hepatic HMGB1 levels in fructose-induced fatty liver

Kameliya Bratoeva, Eleonora Dimitrova, Nikolay Conev, Javor Kashlov, Elena Panajotova, George Stoyanov, Mariya Radanova, Ivan Donev


The study of the processes leading to hepatocellular cell death is important for clinical practice to assess the severity of hepatic impairment as well as for the application of effective interventions to prevent it. Observations show that both cell death processes - apoptosis and necrosis are activated at certain stages of the progression of non-alcoholic fatty liver disease from hepatic steatosis, steatohepatitis and cirrhosis. Currently, the most promising non-invasive specific method for detecting necrotic cell death is non-histone DNA-binding protein with high mobility Group B1 (HMGB1). The aim of this study was to investigate the levels of HMGB1 expression and their relationship to hepatic injury and apoptosis activity in rat liver with fructose-induced metabolic syndrome. The results showed data for metabolic syndrome, microvascular steatosis, statistically reduced levels of HMGB1, an increased ratio of Bax/Bcl2 apoptotic proteins in fructose fed rats.


HMGB1; fatty liver; apoptosis; fructose

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