Helicobacter pylori is a Gram-negative microorganism and an important factor in the pathogenesis of numerous diseases including gastro-intestinal perturbations (peptic ulcer, gastric carcinoma, gastric mucosa-associated lymphoid tissue lymphoma), metabolic, autoimmune, vascular and systemic disorders: in the cardiovascular system - ischemic heart disease, atherosclerosis, Rhein's disease; in the nervous system - headaches and migraines; autoimmune diseases - arthritis, immune thrombocytopenia, Henoch-Schonline's disease, Sjögren's syndrome, autoimmune thyroiditis; skin diseases - rosacea, urticaria, atopic dermatitis, alopecia areata, prurigo nodularis, purpura and others - iron deficiency anemia, growth retardation, amenorrhea, halitosis, aphthous ulcerations. H. pylori was detected in samples from patients with hepatobiliary disorders, hepatic diseases such as hepatocellular carcinoma, cirrhosis and hepatic encephalopathy, nonalcoholic fatty liver disease and fibrosis.
There is a tendency for accumulation of evidence for the role of H. pylori in the etiology and pathogenesis of multiple conditions and diseases. However, this topic requires considerable research before the microorganism's final "accusation" for their presence.
Кацаров К, Върху някои етиопатогенични зависимости между Helicobacter pylori инфекцията и стомашния карцином, Дисертация, 2003
Панов Вл, Helicobacter pylori и афтозен стоматит, Онлайн списание на български зъболекарски съюз, (юли – декември 2016) 2/2016, 29-36.
Панов Вл, Халитоза и Helicobacter pylori, Варненски медицински форум, т. 6, 2017, брой 2, 77-80.
Панов Вл., Helicobacter pylori и устната кухина, Университетско издателство на Медицинския университет „Проф. д-р Параскев Стоянов“– Варна, 2016, 201 стр. ISBN 978-619-7137-83-5
Панов Вл., Лош дъх, Мединформ, 104, 2017, ISBN 978-619-7164-08-4
Стамболийска М, Съвременни клинико-диагностични и терапевтични аспекти на инфекцията с helicobacter pylor. Дисертационен труд за придобиване на образователна и научна степен „Доктор”, Варна, 2014.
Dixon MF. Patterns of inflammation linked to ulcer disease. – In: Baillieres Best Pract Res Clin Gastroenterol, February, 2000, 14 (1): 27–40.
Dogan B. et al. Prevalence of duodenal bulb gastric metaplasia and Helicobacter pylori in Turkey. – In: 5 United European gastroenterology week, Paris, 1996, abstract 13 0334.
Dumrese C, Slomianka, L, Ziegler, U, Choi, SS, Kalia, A, Fulurija, A, Lu, W, Berg, DE, Benghezal, M, Marshall, B, Mittl, PR. The secreted Helicobacter cysteine-rich protein A causes adherence of human monocytes and differentiation into a macrophage-like phenotype. – FEBS Letters, May 2009, 583 (10): 1637–1643.
Hatakeyama M, Higashi, H. Helicobacter pylori CagA: A new paradigm for bacterial carcinogenesis. – Cancer Science, 2005, 96 (12): 835–843.
Hybenova M, Hrda, P, Procházková, J, Stejskal, V, Sterzl, I. The role of environmental factors in autoimmune thyroiditis. – Neuro Endocrinol Lett., 2010; 31 (3): 283–289.
Kilmartin CM. Dental implications of Helicobacter pylori. – J Can Dent Assoc., Sep, 2002; 68 (8): 489–493.
Kim W & Moss, SF. The role of H. pylori in the development of stomach cancer. – Oncology Review, December, 2008, 1 (Suppl 1): 165–168. Retrieved 25 August 2014.
Krasteva A, Kisselova A, Dineva V, Panov Vl, Ivanova A, Krastev Z, Presence of helicobacter pylori in patients with oral malodor. J of IMAB 2013; 19(4):419-421.
Krasteva A, Panov Vl, Krasteva A, Kisselova A, Oral cavity and systemic diseases – Helicobacter pylori and dentistry. Biotechnol & Biotechnol EQ. 2011;25:2447–2451.
Kusters JG, Van Vliet, AH, Kuipers, EJ. Pathogenesis of Helicobacter pylori Infection. – Clin Microbiol Rev, July, 2006, 19 (3): 449–490.
McNulty C. et al. The prevalence of C. pylori in 1447 patients at endoscopy. – Am J Gastroenterol, 1988, v. 83, №9, 1035.
Mégraud F. European Helicobacter Study Group. Evolution of Helicobacter pylori research as observed through the workshops of the European Helicobacter Study Group. – Helicobacter, Nov, 2007, 12 (Suppl 2): 1–5.
Rabelo-Gonçalves EM, Roesler, BM, Zeitune, JM. Extragastric manifestations of Helicobacter pylori infection: Possible role of bacterium in liver and pancreas diseases. – World J Hepatol., Dec, 2015, 28;7 (30): 2968–2979.
Saccà SC, Vagge, A, Pulliero, A, Izzotti, A. Helicobacter pylori infection and eye diseases: a systematic review. – Medicine, December, 2014, 93 (28): e216.
Salama NR, et al. Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori. – Nature Reviews Microbiology, 2013, 11: 385–399.
Shiotani A, Graham, DY. Pathogenesis and therapy of gastric and duodenal ulcer disease. – Med. Clin. North Am., November, 2002, 86 (6): 1447–1466.
Smoot DT. How does Helicobacter pylori cause mucosal damage? Direct mechanisms. – Gastroenterology, December, 1997, 113 (6 Suppl): S31–34; discussion S50.
Suerbaum S, Michetti, P. Helicobacter pylori infection. – N. Engl. J. Med., October, 2002, 347 (15): 1175–1186.
Suganuma M, Yamaguch,i K, Ono, Y, Matsumoto, H, Hayashi, T, Ogawa, T, Imai, K, Kuzuhara, T, Nishizono, A, Fujiki, H. TNF-α-inducing protein, a carcinogenic factor secreted from H. pylori, enters gastric cancer cells. – Int. J. Cancer, July, 2008, 123 (1): 117–122.
Takats A. et al. Frequency of H. Pylori in the 4th and 15th district of Budapest with regard to age topography (an epidemiological analysis surveying 2151 patients). – Gut, 1996, v.39, suppl.2, A 84.
Tsuji S, Kawai, N, Tsujii, M, Kawano, S, Hori, M. Review article: inflammation-related promotion of gastrointestinal carcinogenesis--a perigenetic pathway. – Aliment. Pharmacol. Ther., July, 2003, 18 (Suppl 1): 82–89.
Willyard C. Gut reaction. – Nature, 2011, 479, S5–S7.
Wu Q, Yang, ZP, Xu, P, Gao, LC, Fan, DM. Association between Helicobacter pylori infection and the risk of colorectal neoplasia: a systematic review and meta-analysis. – Colorectal Dis, 2013, 15 (7): e352–364.
Zerrin Önal, Çullu-Çokuğraş, Fügen Işıldak et al. Evaluation of the likelihood of reflux developing in patients with recurrent upper respiratory infections, recurrent sinusitis or recurrent otitis seen in ear-nose-throat outpatient clinics. – The Turkish Journal of Pediatrics, 2015; 57: 258–265.
Zivanoviґc M. et al. Diseases of the upper segment of the gastrointestinal tract and Helicobacter pylori infection. – Med Pregl, 1997, 50(11-12): 465–468.
