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Problems and challenges in assessing fertility and pregnancy in patients with thalassemia major - some key points from transfusion-dependent thalassemia guidelines

Elena Marinova


Over the last decades, the medical care of patients with thalassemia major has improved significantly, with life expectancy being close to that of the rest of the population. At the same time, the quality of life of patients has also improved significantly, and they are able to have families of their own. For medical specialists, this issue raises the question about ensuring normal sexual development, puberty, fertility and pregnancy. Some of the patients suffer hypogonadotrophic hypogonadism and they need assisted reproductive techniques. Fertility and induction of spermatogenesis in male patients with thalassemia is less successful. The suitability to carry to term includes evaluation of cardiovascular system, liver function, dysfunction in other endocrine organs and concomitant viral infections. The article presents the specific characteristics in the planning of spontaneous and assisted pregnancy, the risks associated with that, the drugs that can be applied and the way of delivery.


thalassemia major, fertility, pregnancy

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