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Oral Health And General Somatic Status In Childhood – Overview

Daniela Petrova, Miroslav Stoykov, Sirma Angelova


INTRODUCTION: Deteriorated oral health is most commonly associated with early childhood caries, periodontal and oral mucosa diseases. The link between systemic diseases and their manifestation in the oral cavity is well known and proven.

AIM: The aim of the present literature review is to assess oral health in children suffering from systemic diseases.

MATERIALS AND METHODS: A literature review has been done on the basis of thirty referenced scientific publications using scientific databases - Science Direct, Google Scholar, PubMed and others.

RESULTS: We focused on oral diseases in patients suffering from some systemic diseases. Objects of scientific interest in this study are the specifics of oral status among children with anemia - most often of microcytic type; epilepsy - administering valproic drugs is a risk factor for the development of carious lesions and periodontal diseases in childhood; diabetes mellitus (type 1) – periodontal diseases develop faster and become worse; cardiovascular diseases – congenital heart abnormalities increase the risk of developing caries in early childhood. The daily use of medication, single-parent families, negative attitude towards oral hygiene affect the level of caries progression among children with systemic diseases. The relationship between body mass index and the development of oral diseases has been confirmed. Medications that are used to control and treat chronic systemic diseases such as bronchitis, asthma, allergies and infections, increase the risk of developing carious lesions and erosions on the dental surfaces, especially if these medicines are with low pH and are taken for a long time.

CONCLUSION: The treatment of lesions of the hard tooth tissues, oral mucosa and periodontal apparatus affects positively the control and treatment of existing systemic diseases and vice versa – cured systemic diseases reduce the manifestation or progression of oral diseases.


systemic diseases, caries, periodontal diseases, diseases of the oral mucosa, childhood

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Adair S.M. - The Oral/Systemic Connection: Where’s ECC? What’s Our Role?

Al-Shareed M, Angeletou A, Ashley PF, Lucas VS, Whitehead B, Roberts GJ. An investigation of the oral status and reported oral care of children with heart and heart-lungs transplants. Int J Paediatr Dent. 2000 Dec;10(4):298-305

Amar S, Gokce N, Morgan S, Loukideli M, Van Dyke TE, Vita J. Periodontal disease is associated with brachial artery endothelial dysfunction and systemic inflammation. Arterioscler Thromb Vasc Biol 2003; 23:1245–1249

BIGEARD, L. The role of medication and sugars in pediatric dental patients. Dent. Clin. North Am., v.44, n.3, p.443- 456, 2000

Cameron A. C., Widmer R. P. Handbook of Pediatric Dentistry. 3rd. Mosby Elsevier; 2008

De Menezes V.A., Cavalcanti G., Mora C. Garcia A.F.G., Leal R.B. -Pediatric medicines and their relationship to dental caries

DeStefano F, Anda RF, Kahn S, Williamson DF, Russell CM - Dental disease and the risk of coronary heart disease and mortality. BMJ 1993; 306: 688–691

Drewnowski A, Popkin BM. The nutrition transition: new trends in the global diet. Nutr Rev. 1997;55(2):31-43

Drewnowski A. Nutrition transition and global dietary trends. Nutrition.2000;16(7-8):486-487

Edalat A. ,M. Abbaszadeh,M. Eesvandi, and A. Heidari-The Relationship of Severe Early Childhood Caries and Body Mass Index in a Group of 3- to 6-year-old Children in Shiraz

Fonseca MA, Evans M, Teske D, Thikkurissy S, Amini H. The impact of oral health on the quality of life of young patients with congenital cardiac disease. Cardiol Young.2009 Jun;19(3):252-6

Grant CC, Wall CR, Brewster D, Nicholson R, Whitehall J, Super L, et al. Policy statement on iron deficiency in pre-schoolaged children. J Paediatr Child Health 2007;43:513e21

Gurbuz T, Tan H. - Oral health status in epileptic children

Grau A, Buggle F, Ziegler C et al. - Association between acute cerebrovascular ischemia and chronic and recurrent infection. Stroke 1997; 28: 1724–1729

Hallett KB, Radford DJ, Seow WK. Oral health of children with congenital cardiac diseases: a controlled study. Pediatr Dent. 1992 Jul-Aug;14(4):224-30

Hausen H. Caries prediction: state of the art. Community Dent Oral Epidemiol. 1998;25(1):87-96

Hoffman JIE, Kaplan S. The incidence of congenital heart disease. J Am Coll Cardiol. 2002 Jun 19;39(12):1890-900

Linnett V, Seow WK. Dental erosion in children: a literature review. Pediatr Dent. 2001;23(1):37-43

Lustig RH, Schmidt LA, Brindis CD. Public health: the toxic truth about sugar. Nature. 2012;482(7383):27-29

MACKIE, I. C.; WORTHINGTON, H. V.; HOBSON, P. An investigation into sugar containing and sugar-free over-the counter medicines stocked and recommended by pharmacists in the north western region of England. Br. Dent. J., v.175, n.3, p.93-98, 1993

Mercanoglu F, Oflaz H, Oz O et al. Endothelial dysfunction in patients with chronic periodontitis and its improvement after initial periodontal therapy. J Periodontol 2004; 75: 1694–1700

Migita DS, Christakis DA Saints. The Saint-Frances Guide to Pediatrics. Philadelphia: Lippincott, Williams and Wilkins,2003

Mohebbi SZ, Virtanen JI, Vahid-Golpayegani M, Vehkalahti MM.Feeding habits as determinants of early childhood caries in a population where prolonged breastfeeding is the norm. Community Dent Oral Epidemiol 2008;36:363e9.)

Moynihan P, Petersen PE. Diet, nutrition and the prevention of dental diseases. Public Health Nutr. 2004;7(1A):201-226

Moynihan P. The role of diet and nutrition in the aetiology and prevention of oral diseases. Bull World Health Organ. 2005;83(9):694-699

Naidoo S, Oral health and nutrition for children under five years of age: a paediatric food-based dietary guideline

NEVES, B. G.; PIERRO, V. S.; SILVA, M. L. C. Perceptions and attitudes among parents and guardians on the use of pediatric medicines and their cariogenic and erosive potential. Ciênc. Saúde Coletiva, v.12, n.5, p.1295-1300, 2007

Nishimura F., Takahashi K., Kurihara M., Takashiba S., Murayama Y. Periodontal disease as a complication of diabetes mellitus. Annals of Periodontology. 1998;3(1):20–29. doi: 10.1902/annals.1998.3.1.20)

Novotna M., Podzimek S., Broukal Z., Lencova E., Duskova J. -Periodontal Diseases and Dental Caries in Children with Type 1 Diabetes Mellitus)

Nur B.G., Tanrıver M., Altunsoy M., Atabay T., Intepe N., - The prevalence of iron deficiency anemia in children with severe early childhood caries undergoing dental surgery under general anesthesia

Oliveira MA, Oso´rio MM. Cow’s milk consumption and iron deficiency anemia in children. J Pediatr (Rio J) 2005;81:361e7

Petersen PE. The World Oral Health Report, 2003. Continuous improvement of oral health in the 21st century: the approach of the World Health Organization Oral Programme. Geneva: WHO; 2003

Petersen PE, Bourgeois D, Ogawa H, et al. The global burden of oral diseases and risks to oral health. Bull World Health Organ.2005;83(9):661-669

Pimente E.L.C., Azevedo V.M.P., Castro R.A.L., Reis L.C., Lorenzo A. - Caries experience in young children with congenital heart disease in adeveloping country

Plutzer K, Keirse MJNC. Incidence and prevention of early childhood caries in one- and two-parent families. Child Care Health Dev. 2011 Jan;37(1):5-10

Preshaw P. M., Alba A. L., Herrera D., et al. Periodontitis and diabetes: a two-way relationship. Diabetologia. 2012;55(1):21–31. doi: 10.1007/s00125-011-2342-y.

Putnam JJ, Allshouse JE. Food consumption, prices, and expenditures,1970-1997. Washington, DC: Food and Consumers Economics Division,Economic Research Service, US Department of Agriculture; 1999

Rautemaa R., A. Lauhio, M. P. Cullinan and G. J. Seymour - Oral infections and systemic disease—an emerging problem in medicine

SHAW, L.; GLENWRIGHT, H. D. The role of medications in dental caries formation: need for sugar-free medication for children. Pediatrician, v.16, n.3-4, p.153-155, 1989

Sheiham A. Dental caries affects body weight, growth and quality of life in pre-school children. Br Dent J 2006;201: 625e6

Silva DB, Souza IPR, Cunha MCSA. Knowledge, attitudes and status of oral health in children at risk for infective endocarditis. Int J Paediatr Dent. 2002 Mar;12(2):124-31

Steksn-Blicks C, Rydberg A, Nyman L, Asplund S, Svaberg C. Dental caries experience in children with congenital heart disease: a case-control study. Int J Pediatr Dent. 2004 Mar;14(2):94-100

Syrjälä A.-M. H., Kneckt M. C., Knuuttila M. L. E. Dental self-efficacy as a determinant to oral health behaviour, oral hygiene and HbA1c level among diabetic patients. Journal of Clinical Periodontology. 1999;26(9):616–621. doi: 10.1034/j.1600-051x.1999.260909.x

Tang R.S., Huang M.C., Huang S.T. - Relationship between dental caries status and anemia in children with severe early childhood caries

Thomas CW, Primosch RE. Changes in incremental weight and well-being of children with rampant caries following complete dental rehabilitation. Pediatr Dent. 2002; 24: 109–113

Tomбs Carmona I, Diz Dios P, Scully C. Efficacy of antibiotic prophylactic regimens for the prevention of bacterial endocarditis of oral origin. J Dent Res. 2007 Dec;86(12):1142-59

Tonetti MS, D’Aiuto F, Nibali L et al. Treatment of periodontitis and endothelial function. N Engl J Med 2007; 356: 911–920

Valtonen VV. - Role of infections in atherosclerosis. Am Heart J 1999; 138: S431–S433

Wilson W, Taubert KA, Gewitz M, Lockhart PB, Baddour LM, Levison M, et al. Prevention of infective endocarditis.Guidelines from the American Heart Association. J AmDent Assoc (Internet). 2008 Jan (cited 2012 Jan 9);139 Suppl 1:3S-24S. Available from: http// suppl_1/3S.full.pdf+html. Review. Erratum in: J Am Dent Assoc. 2008 Mar; 139(3):253. American Heart Association

World Health Organization/Food and Agricultural Organization of the United Nations. Diet, nutrition and the prevention of chronic diseases. Geneva: WHO; 2003

Учебник по неврология – под редакцията на проф. д-р П. Шотеков



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