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Varna Medical Forum

Hemolytic uremic syndrome - pathogenesis and laboratory

Stoyanka Tancheva, Hilda Habib, Maria Petkova, Daniela Malcheva

Abstract

Introduction: Our interest was provoked by a patient who, after intestinal inflammation accompanied by acute diarrheal syndrome, had sharply elevated urea levels, creatinine, uric acid and potassium in the blood, indirect bilirubin and lactate dehydrogenase (LDH). Peripheral blood pacing (PKK) automated analysis revealed anemia with a platelet count of less than 100x10 / 9 / L and a morphological analysis of blood smears on Romanowsky-Giemsa staining showed the presence of schizocytic forms of the cells of the erythrocyte line.

Materials and Methods: As a material, we used whole blood taken with an EDTA anticoagulant, tested on a Mindray-BC-3000Plus automatic hematological counter, and a blood smear stained by Romanowsky-Giemsa, as well as blood for biochemical analysis, which we studied with a biochemical analyzer Roche - Cobas Integra 400Plus.

Results and Discussion: Laboratory results of hemolytic anemia, thrombocytopenia and acute renal failure (ARF), combined with the clinical picture of the patient, have led us to the diagnosis of hemolytic uremic syndrome (HUS).

Conclusion: When combined with the indicated clinic and laboratory findings, it is always necessary to think of a differential diagnostic plan for HUS. HUS is characterized by recurrent episodes of acute disease leading to terminal renal failure.


Keywords

hemolytic uremic syndrome, thrombocytopenia, Paneth cells, acute renal failure

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DOI: http://dx.doi.org/10.14748/vmf.v8i0.6347

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