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Tools for quality of life assessment in patients with obstructive sleep apnea

Liudmil Matev, Hristina Arnautska


Obstructive sleep apnea (OSA) is found in 24% of men and 9% of older women. Given the high prevalence of the OSA syndrome and its effects on physical and mental function, the quality of life (QoL) in OSA has aroused great interest in the modern scientific literature. The interest in QoL in patients with OSA is so great that various studies are being conducted. The purpose of this article is to present the various tools for assessing QoL in patients with OSA. For the period January 2020 - June 2020, in the available database (PubMed, BioMedCentral, ScienceDirect, Scopus, Web of Science), a systematic analysis of scientific publications examining the assessment of QoL in patients with OSA was performed. This review illustrates the variety of tools used to study the assessment of health-related QoL and OSA. The published data in the research are mostly limited to the assessment of CPAP, and the effects on QoL after the performed surgical, dental and behavioral treatments for OSA remain largely unexplored.


quality of life, generic questionnaires, specialized questionnaires, obstructive sleep apnea

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Йорданов Й., Златарова З., Ненчева Б., Стойчева З. Оценка на качеството на живот при болни с първична откритоъгълна глаукома. Глаукоми, ISSN 1314-7692, Toм VII, бр. 1, 2018, 5-14

Йорданов Й., Ненчева Б., Стойчева З. Kaчество на живот при пациенти с първична откритоъгълна глаукома. Варненски медицински форум, т.7, бр. 1, 2018, 45-48

Йорданов Й., Ненчева Б., Стойчева З. Качество на живот при пациенти с първична откритоъгълна глаукома в зависимост от проведеното лечение. Варненски медицински форум, т.7, бр. 1, 2018, 49-52

Appleton SL, Vakulin A, McEvoy RD, et al. Undiagnosed obstructive sleep apnea is independently associated with reductions in quality of life in middle-aged, but not elderly men of a population cohort. Sleep & Breathing. 2015;19(4):1309–16. doi: 10.1007/s11325-015-1171-5

Batool–Anwar S, Goodwin JL, Kushida CA, et al. Impact of continuous positive airway pressure (CPAP) on quality of life in patients with obstructive sleep apnea (OSA) Journal of sleep research. 2016 doi: 10.1111/jsr.12430

Bergner M, Bobbitt RA, Carter WB, Gilson BS. The Sickness Impact Profile: development and final revision of a health status measure. Med Care 1981;19:787–805

Bes A, Aran X, Gea J, Orozco-Levi M, Felez MA, Broquetas JM. Somnolence. Quality of life and quality of sleep in snorers, with and without sleep apnea syndrome. Am J Respir Crit Care Med 1996;153:A353

Bjorner, J.B.; Wolden, M.L.; Gundgaard, J.; Miller, K. Benchmarks for interpretation of score differences on the SF-36 survey for patients with diabetes. Value Health 2013, 16, 993–1000

Bolitschek J, Schmeiser-Rieder A, Schobersberger R, Rosenberger A, Kunze M, Aigner K. Impact of nasal continuous positive airway pressure treatment on quality of life in patients with obstructive sleep apnea. Eur Respir J 1998;11:890–894

Campos-Rodriguez F, Martinez-GarciaMA, Reyes-Nunez N, et al. Role of sleep apnea and continuous positive airway pressure therapy in the incidence of stroke or coronary heart disease in women. AmJ Respir Crit Care Med. 2014;189:1544e1550

Cohen SR, Suzman K, Simms C, Burstein FD, Riski J, Montgomery G. Sleep apnea surgery vs tracheostomy in children: an exploratory study of the comparative effects on quality of life. Plast Reconstr Surg 1998;102:1855–1864

D’Ambrosio C, Bowman T, Mohsenin V. Quality of life in patients with obstructive sleep apnea: effect of nasal continuous positive airway pressure — a prospective study. Chest 1999;115(1):123–129

De Haan R, Aaronson N, Limburg M, Hewer RL, van Crevel H. Measuring quality of life in stroke. Stroke 1993;24:320–327

Dutt N, Janmeja AK, Mohapatra PR, Singh AK. Quality of life impairment in patients of obstructive sleep apnea and its relation with the severity of disease. Lung India. 2013;30(4):289-294

Engleman HM, Douglas NJ. Sleep. 4: Sleepiness, cognitive function, and quality of life in obstructive sleep apnoea/hypopnoea syndrome. Thorax 2004; 59: 618-622

EuroQol Group. The EuroQol quality of life scale. Revised 1993. In: McDowell I, Newell C, editors. Measuring health: a guide to rating scales and questionnaires, 2nd ed. Oxford, UK: Oxford University Press, 1996

Finn L, Young T, Palta M, Fryback DG. Sleep-disordered breathing and self-reported general health status in the Wisconsin Sleep Cohort Study. Sleep. 1998;21(7):701-706

Flemons WW, Tsai W. Quality of life consequences of sleep disordered breathing. Allergy Clin Immunol 1997;99(2):S750–S756

Flemons WW, Reimer MA. Development of a disease-specific health-related quality of life questionnaire for sleep apnea. Am J Respir Crit Care Med 1998;158:494–503

Franco Jr RA, Rosenfeld RM, Rao M. Quality of life for children with obstructive sleep apnea. Otolaryngol Head Neck Surg 2000;123:9–16

Gall R, Isaac L, Kryger M. Quality of life in mild obstructive sleep apnea. Sleep 1993;16:S59–S61

Garbarino, S.; Lanteri, P.; Durando, P.; Magnavita, N.; Sannita, W.G. Co-morbidity, mortality, quality of life and the healthcare/welfare/social costs of disordered sleep: A rapid review. Int. J. Environ. Res. Public Health 2016, 13, 831

Guyatt GH, Feeny DH, Patrick DL. Measuring health-related quality of life. Ann Intern Med 1993;118:622–629

Heinisch M, Ludwig M, Bullinger M. Psychometrische testung der munchner lebensqualitatsfragenbogen. In: Bullinger M, Ludwig M, von Steinbuchel N, editors. Lebensqualitat bei cardiovaskularen erkrankungen, grundlagen, messverfahren, ergebnisse, dimensionen liste (MLDL), 1991. pp. 73–90

Hunt SM, McKenna SP, McEwen J, Williams J, Papp E. The Nottingham Health Profile: subjective health status and medical consultations. Soc Sci Med A 1981;15(3 part 1):221–229

Jenkinson C, Stradling J, Peterson S. Comparison of three measures of quality of life outcome in the evaluation of continuous positive airways pressure therapy for sleep apnoea. Sleep 1997;6:199–204

Lee W, Lee SA, Ryu HU, et al. Quality of life in patients with obstructive sleep apnea: Relationship with daytime sleepiness, sleep quality, depression, and apnea severity. Chronic Respiratory Disease. 2016;13(1):33–9. doi: 10.1177/1479972315606312

Lopes C, Esteves AM, Bittencourt LR, et al. Relationship between the quality of life and the severity of obstructive sleep apnea syndrome. Brazilian Journal of Medical & Biological Research. 2008;41(10):908–13. doi: S0100-879X2008005000036

Lоth S, Petruson P, Wire´n L, Wilhelmsen L. Better quality of life when nasal breathing of snoring men is improved at night. Arch Otolaryngol Head Neck Surg 1999;125:64–67

Milkov M., Nedev P. Quality of life of patients with suspected hearing reduction. Journal of International Advanced Otology, 2015/5/2, 11

Milkov M. Vestibular and hearing disorders in obstructive sleep apnea patients. Journal of the Union of Scientists-Varna. Medicine and Ecology Series, 2018, 23, 1, 45-50

Milkov M., Petrov P., Madjova C. Effective management of obstructive sleep apnea screening and diagnostics for drivers in Bulgaria. Sleep Medicine, 2019/12/1, 64, S239

Milkov M. Positional obstructive sleep apnea as a new interdisciplinary challenge. International Bulletin of Otorhinolaryngology. 2019, 15, 2, 16-20

Parish JM, Lyng PJ. Quality of life in bed partners of patients with obstructive sleep apnea or hypopnea after treatment with continuous positive airway pressure. Chest. 2003;124(3):942-947

Patrick DL, Peach H. Disablement in the community. Oxford, UK: Oxford University Press, 1989

Piccirillo JF, Schechtman KB, Edwards D, Sher AE, White DL. Development of the obstructive sleep apnea quality of life measure (abstract). Sleep 1994:A443

Piccirillo JF, Gates GA, White DL, Schectman KB. Obstructive sleep apnea treatment outcomes pilot study. Otolaryngol Head Neck Surg 1998;118:833–844

Reimer MA, Flemons WW. Quality of life in sleep disorders. Sleep Medicine Reviews. 2003;74:335–49. doi: S1087079201902205

Scalo, J.; Desai, P.; Rascati, K. Insomnia, hypnotic use, and health-related quality of life in a nationally representative sample. Qual. Life Res. 2015, 24, 1223–1233

Sher AE. An overview of sleep disordered breathing for the otolaryngologists. Ear Nose Throat J 1999;78(9):694–706

Siccoli MM, Pepperell JC, Kohler M, et al. Effects of continuous positive airway pressure on quality of life in patients with moderate to severe obstructive sleep apnea: data from a randomized controlled trial. Sleep. 2008;31(11):1551–8

Silva, G.E.; Goodwin, J.L.; Vana, K.D.; Quan, S.F. Obstructive sleep apnea and quality of life: Comparison of the SAQLI, FOSQ, and SF-36 questionnaires. Southwest J. Pulm. Crit. Care 2016, 13, 137–149

Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. The Report of an American Academy of Sleep Medicine Task Force. Sleep 1999;22:667-89

Ware JE, Snow KK, Kosinski M, Gandek B. SF-36 Health Survey, manual and interpretation guide. Boston, MA: The Health Institute, New England Medical Center, 1993

Ware JE. The SF-36 health survey. In: Spilker B, editor. Quality of life and pharmacoeconomic in clinical trials, 2nd ed. Philadelphia, PA: Lippincott-Raven, 1996. p. 337–345

Weaver TW, Laizner AM, Evans LK, Maislin G, Chugh DK, Lyon K, Smith PL, Schwartz AR, Redline S, Pack AI, Dinges DF. An instrument to measure functional status outcomes for disorders of excessive sleepiness. Sleep 1997;20(10):835–843.

Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med 1993; 328: 1230-1235



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