Osteoarthritis, a joint disease characterized by cartilage degeneration, osteophyte formation, and changes in the joint capsule, affects multiple structures surrounding the joint, including muscles, tendons, and ligaments.
With a growing interest in non-drug and non-surgical approaches for osteoarthritis prevention and treatment, physical and rehabilitation medicine, along with mud therapy, have gained attention.
Mud, a natural product resulting from various chemical, biological, and microbiological processes involving soil particles and organic and inorganic compounds, possesses remarkable anti-inflammatory, analgesic, and immune-stimulant properties. Furthermore, it enhances blood circulation, metabolic activity, and strengthens the bone system. The high mineral concentration in mud from sea estuaries is believed to give it unique healing properties.
The specific effects of estuarine mud stem from its composition: sulphur and humic acids inhibit hyaluronidase and stimulate the formation of cytokines, which determine its chondroprotective and anti-inflammatory effects. Alongside traditional osteoarthritis treatment options like medication, physiotherapy, balneotherapy, lifestyle changes, and surgery, mud therapy stands out as a promising alternative.
Studies have demonstrated that Liman mud significantly reduces inflammation, eases pain, and boosts the immune system. Additionally, it enhances blood circulation and metabolic processes, leading to improved tissue nourishment and faster regeneration. The healing properties of mud are attributed to a complex interaction of thermal, chemical, mechanical, electrodynamic, biological, and other factors. In particular, thermal and chemical elements play a crucial role in determining the outcomes of the healing process.
Simona Bellometti, Maurizio Cecchettin, Lauro Galzigna. 1997. "Mud pack therapy in osteoarthrosis: Changes in serum levels of chondrocyte markers." Clinica Chimica Acta Volume 268, IPages 101-106.
Dischereit G, Goronzy JE, Müller-Ladner U, Fetaj S, Lange U. 2019. "Effects of serial mud baths on inflammatory rheumatic and degenerative diseases." Z Rheumatol. 2019;[Article in German; abstract referenced.] 78(2):143-154. doi:10.1007/s00393-018-0582-7.
Ersin Odabasi, Mustafa Turan, Hakan Erdem, and Faruk Tekbas. 2008. "Does Mud Pack Treatment Have Any Chemical Effect? A Randomized Controlled Clinical Study." The Journal of Alternative and Complementary Medicine.J. 559-565; http://doi.org/10.1089/acm.2008.0003.
Güngen, G., Ardic, F., Fιndıkoğlu, G. et al. 2012). "The effect of mud pack therapy on serum YKL-40 and hsCRP levels in patients with knee osteoarthritis." Rheumatol Int 32, 1235–1244; https://doi.org/10.1007/s00296-010-1727-4.
Bellometti S, Galzigna L. 1998. "Serum levels of a prostaglandin and a leukotriene after thermal mud pack therapy." Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research. Apr;46(4):140-145.
Sukenik, S., Buskila, D., Neumann, L. et al. 1992. "Mud pack therapy in rheumatoid arthritis." Clin Rheumatol 11, 243–247; https://doi.org/10.1007/BF02207966.
Fraioli A, Mennuni G, Fontana M, et al. 2018. "Efficacy of spa therapy, mud-pack therapy, balneotherapy, and mud-bath therapy in the management of knee osteoarthritis. A systematic review." Biomed Res Int. 2018:1042576. doi:10.1155/2018/1042576.
Cozzi F, Raffeiner B, Beltrame V, et al. 2015. "Effects of mud-bath therapy in psoriatic arthritis patients treated with TNF inhibitors. Clinical evaluation and assessment of synovial inflammation by contrast-enhanced ultrasound (CEUS)." Joint Bone Spine. 82(2):104-108. doi:10.1016/j.jbspin.2014.11.002.
Cozzi F, Ciprian L, Carrara M, et al. 2018. "Balneotherapy in chronic inflammatory rheumatic diseases—a narrative review." nt J Biometeorol. 62(12):2065-2071. doi:10.1007/s00484-018-1618-z.
Hua Liu*, Chao Zeng*, and al. 2013. "The effect of mud therapy on pain relief in patients with knee osteoarthritis: A meta-analysis of randomized controlled trials." Journal of International Medical Research 41(5) 1418–1425; DOI: 10.1177/0300060513488509.
Espejo-Antúnez L, Cardero-Durán, MA, et al. 2013. "Clinical effectiveness of mud pack therapy in knee osteoarthritis." Rheumatology (Oxford). 52(4):659-668. doi:10.1093/rheumatology/kes322.
Стаматов С. 1984. Балнеология и лечебен туризъм. София: Медицина и физкултура.
Едрева, В., Д. Кръстева. 2000. "Балнеолечение, водолечение, калолечение. София: ИК "Иврай “.
Кръстева, Д. 1985. Калолечение. . София: Медицина и физкултура.