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Varna Medical Forum

The central canal in adult primates as a proliferative niche

Desislava Marinova, Meglena Angelova


The formation of the functionally active neurons is known as neurogenesis. The presence of stem cells in the central nervous system (CNS) of adult mammals has been demonstrated, showcasing their ability to self-renew and subsequently differentiate into all major cell subtypes of nervous tissue A well-established proliferative niche is the subventricular zone of the telencephalon and the central canal of the spinal  cord.  In this study, conducted on mature Japanese monkeys, subjects were perfused with the thymidine analogue BrdU according to a pre-established protocol and euthanized at varying intervals after the last infusion. We observed a statistically significant increase in the density of newly formed cells only in the group with the shortest survival period (2 hours after BrdU) compared to those with longer survival periods (2, 5, 10 weeks). When examining the proliferative activity of progenitors at three anatomical levels, with focus on the region of the central canal, within each experimental group, we registered a statistically significant increase at the cervical segment level in the short-term experimental group compared to the thoracic and lumbar segments in the same animals.


spinal cord, central canal, proliferation, BrdU

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