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Autophagy - molecular mechanisms and its role in neoplastic process

Nadezhda Stefanova, Maria Tsaneva, Antoniya Hachmeriyan, Ivan Donev


Autophagy is a biological process that enables the recycling of cellular components to maintain cell sur- vival. It functions at relatively low levels constantly in mammalian cells. It can be induced by starvation and cellular stress to provide energy for protein synthesis, allowing the organism to survive. Blocking the autoph- agy initiates tumor processes by accumulating of dys- functional proteins aggregates and/or by inducing a chronic inflammation. In well established tumors, au- tophagy can support tumor cell survival. Knowing the exact mechanisms of the autophagy will allow the ap- plication of new therapeutic strategies in the treatment of malignant tumors


autophagy; tumorogenesis; cell survival; treatment

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