In spite of the enormous volume of research in atherosclerosis, the etiological understanding of atherogenesis is still beyond compare. e Framingham Heart Study (started 1948) (1) identified the major risk factors and this concept has become an important part of the modern medical knowledge and has led to effective preventive strategies in clinical practice. But correlation is not causation. In an attempt to identify etiological factors and the immune mechanisms in atherogenesis, Georg Wick and his co-workers in a series of experiments obtained intriguing results, which confirm that atherosclerosis may be induced in rabbits by treatment with a variety of agents containing heat-shock protein of molecular weight 60 kD (HSP60) (2-7).
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