Clinical and experimental studies demonstrate an interaction among bones, adipose tissue and diabetes mellitus: obese women have lower risk of fractures, whereas diabetes and hypertension were associated with osteopenia and osteoporosis. Today, bone is considered not solely as a supporting and protective structure, but also an active endocrine organ producing secretory proteins collectively termed osteokines. In this presentation, the role of two of these factors, leptin and osteocalcin, as well as the transcription factors FOXO1 and ATF4, in the control of glucose and energy homeostasis is briefly highlighted.
Adipobiology 2010; 2: 67-71.
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