Recent article of Edwin Mariman published in this volume of Adipobiology brings new interesting view on the mechanism involved in weight loss and regain: changes of the cell volume and content of adipocytes and their impact on secretion of adipokines. While acute changes of cell volume are well known to be integrated into a signal transduction network affecting various functions including secretion, macromolecule biosynthesis and degradation, cell migration, proliferation and apoptosis, impact of chronic changes of cell volume on function have been rarely considered.
Adipobiology 2011; 3: 17-18.
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