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Adipobiology

Adipomyobiology Of Obesity And Related Diseases: Therapy Insights

George N. Chaldakov, Luigi Aloe, Manlio Vinciguerra, Anton B. Tonchev, Marco Fiore, Levent Oztürk

Abstract

Today, the most widespread disease around the world is not COVID-19 or any other communicable disease. Indeed, obesity and type 2 diabetes mellitus (T2DM) have been recognized as the main risks for cardiometabolic diseases (CMD) and their morbidity and mortality signature. Recent studies revealed that the adipose tissue and the skeletal muscles may function as endocrine and paracrine organs secreting multiple proteins termed adipokines and myokines respectively. Some of them being produced both by adipose and skeletal tissue, hence dubbed adipomyokines. The contents of this review highlights the following two topics: (i) the progress in knowledge of adipomyokines may lead to better understandings of the process of pathogenesis of obesity and related CMD, and (ii) in-depth studies on Palade-Blobel’s general theory of cell protein secretion may allow to explore its pharmacological potentials for new therapies of these diseases. This may open up an intriguing line of scientific enquiry that will unite adipobiologists and myobiologists in the fight against obesity and related CMD.

Keywords

adipomyokines, irisin, adiponectin, BDNF, obesity, cardiometabolic diseases, protein secretion, therapy

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DOI: http://dx.doi.org/10.14748/adipo.v11.8561

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About The Authors

George N. Chaldakov
Departments of Anatomy and Cell Biology and Translational Stem Cell Biology, Research Institute, Medical University, Varna, Bulgaria
Bulgaria

Luigi Aloe
Fondazione Iret Tecnopolo R. Levi-Montalcini Rome, Italy
Italy

Manlio Vinciguerra
Department of Translational Stem Cell Biology, Research Institute, Medical University, Varna, Bulgaria

Anton B. Tonchev
Departments of Anatomy and Cell Biology and Translational Stem Cell Biology, Research Institute, Medical University, Varna, Bulgaria
Bulgaria

Marco Fiore
Institute of Biochemistry and Cell Biology, Section of Neurobiology, National Research Council (CNR), Rome, Italy
Italy

Levent Oztürk
Department of Physiology, Trakya University, Edirne, Turkey
Turkey

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