Chronic Kidney Disease (CKD) is a complex, multisystem process. There are multiple changes in terms of etiology, development of the process and the complications in adults and children.
The current review discusses the new aspects in the literature in regard to CKD, focusing mainly on the bone changes and physical activity in patients in pediatric population. Renal osteodystrophy is linked not only to decreased bone density, due to decreased production of vitamin D, but also to rickets changes. So far there is no data in the literature for physiotherapy treatment, currently practiced with children with CKD. Studies in recent years pay attention to physical activity in the pediatric population.
Nelson Texbook of Pediatrics, 20 edition, 2016, Chapter 535
Tasic V, Janchevska A, Emini N, Sahpazova E, Gucev Z, Polenakovic M. Chronic kidney disease - pediatric risk factors. Pril (Makedon Akad Nauk Umet Odd Med Nauki). 2016;37(1):9-13. doi: 10.1515/prilozi-2016-0003. PMID: 27442412.
Laster M, Denburg M, Okuda Y, Kumar J, Furth S, Warady B, Kalantar-Zadeh K, Norris K, Salusky IB. Race and Ethnicity Predict Bone Markers and Fracture in Pediatric Patients With Chronic Kidney Disease. J Bone Miner Res. 2021 Feb;36(2):298-304. doi: 10.1002/jbmr.4182. Epub 2020 Oct 23. PMID: 32960469.
Hruska KA, Sugatani T, Agapova O, Fang Y. The chronic kidney disease - Mineral bone disorder (CKD-MBD): Advances in pathophysiology. Bone. 2017 Jul;100:80-86. doi: 10.1016/j.bone.2017.01.023. Epub 2017 Jan 22. PMID: 28119179; PMCID: PMC5502716.
Salusky IB, Kuizon BG, Jüppner H. Special aspects of renal osteodystrophy in children. Semin Nephrol. 2004 Jan;24(1):69-77. doi: 10.1053/j.semnephrol.2003.08.009. PMID: 14730512.
Jorgetti V, Drüeke TB. Value of the new bone classification system for pediatric patients with chronic kidney disease. Clin J Am Soc Nephrol. 2010 Oct;5(10):1730-1. doi: 10.2215/CJN.07620810. Epub 2010 Sep 28. PMID: 20876672.
Bakkaloglu SA, Wesseling-Perry K, Pereira RC, Gales B, Wang HJ, Elashoff RM, Salusky IB. Value of the new bone classification system in pediatric renal osteodystrophy. Clin J Am Soc Nephrol. 2010 Oct;5(10):1860-6. doi: 10.2215/CJN.01330210. Epub 2010 Jul 15. PMID: 20634327; PMCID: PMC2974387.
Pereira RC, Andersen TL, Friedman PA, Tumber N, Salusky IB, Wesseling-Perry K. Bone Canopies in Pediatric Renal Osteodystrophy. PLoS One. 2016 Apr 5;11(4):e0152871. doi: 10.1371/journal.pone.0152871. Erratum in: PLoS One. 2016;11(5):e0155663. PMID: 27045269; PMCID: PMC4821625.
Abd-Elmonem AM, Al-Tohamy AM, Galal RE, Abd-Elhalim FA. Effects of progressive resistance exercises on quality of life and functional capacity in pediatric patients with chronic kidney disease: a randomized trail. J Musculoskelet Neuronal Interact. 2019 Jun 1;19(2):187-195. PMID: 31186389; PMCID: PMC6587089.
Akber A, Portale AA, Johansen KL. Use of pedometers to increase physical activity among children and adolescents with chronic kidney disease. Pediatr Nephrol. 2014 Aug;29(8):1395-402. doi: 10.1007/s00467-014-2787-6. Epub 2014 Mar 20. PMID: 24648129; PMCID: PMC4074553.
Sabath RJ. Exercise evaluation of children with end-stage renal disease. Adv Ren Replace Ther. 1999 Apr;6(2):189-94. doi: 10.1016/s1073-4449(99)70051-8. PMID: 10230889.