Scientific Online Resource System

Actual Nephrology

Tubulopathy in Patients with Beta Thalassemia Major

Liliya Stoyanova, Svetla Staykova, Triphon Chervenkov

Abstract

The iron overload and the development of secondary hemosiderosis in patients with β-thalassemia major lead to organ damages, including kidney disorders from an early childhood. Contemporary urinary markers such as neutrophil gelatinase-association lipocalin, β2-microglobulin, and N-acetyl-β-D-glucosaminidase could be a useful tool for clinicians in diagnosing early tubular lesions. The current study was performed in 44 patients with β-thalassemia major and 30 controls. All participants were tested for NGAL, β2-MG, and NAG in the first sample morning urine using the ELISA method. The results showed statistically significant difference in urinary NGAL between the two examined groups. This marker indicates very early damage to the proximal tubule before cell death occurs.

Keywords

β-thalassemia major, β2-microglobulin (β2-MG), neutrophil gelatinase-associated lipocalin (NGAL), N-acetyl-beta-D-glucosaminidase (NAG)

Full Text


References

Renal tubular function in patients with beta-thalassaemia major in Zahedan, southeast Iran, Sadeghi-Bojd S, Hashemi M, Karimi M. Singapore Med J. 2008 May;49(5):410-2. PMID: 18465053) ;

Renal tubular dysfunction in pediatric patients with beta-thalassemia major. Ahmadzadeh A, Jalali A, Assar S, Khalilian H, Zandian K, Pedram M. Saudi J Kidney Dis Transpl. 2011 May; 22(3):497-500. PMID: 2156630;

Ponticelli C, Musallam KM, Cianciulli P, Cappellini MD: Renal complications in transfusion-dependent beta thalassaemia. Blood Rev 24: 239–244, 2010;

Musallam KM, Taher TA. Mechanisms of renal disease in β-thalassemia.J Am Soc Nephrol. 2012;23:1299–1302;

Zhou XJ, Laszik Z, Wang XQ, Silva FG, Vaziri ND. Association of renal injury with increased oxygen free radical activity and altered nitric oxide metabolism in chronic experimental hemosiderosis. Lab Invest. 2000;80:1905–1914;

Hashemieh M, Radfar M, Azarkeivan A, Mohammad S, Tabatabaei T , Nikbakht S, Yaseri M , Sheibani K., Renal Hemosiderosis among Iranian Transfusion Dependent β-Thalassemia Major Patients, Int J Hematol Oncol Stem Cell Res. 2017 Apr 1; 11(2): 133–138;

Hashemieh M, Radfar M, Azarkeivan A, Mohammad S, Tabatabaei T, Nikbakht S, Yaseri M, Sheibani K., Renal Hemosiderosis among Iranian Transfusion Dependent β-Thalassemia Major Patients, Int J Hematol Oncol Stem Cell Res. 2017 Apr 1; 11(2): 133–138;

Grossman H, Dische MR, Winchester PH, Canale V. Renal enlargement in thalassemia major.Radiology.1971;100:645–648;

BadeliH, Baghersalimi A , Eslami S et al., Early Kidney Damage Markers after Deferasirox Treatment in Patients with Thalassemia Major: A Case-Control Study, Oxidative Medicine and Cellular Longevity, vol. 2019, Article ID 5461617, 8 pages, 2019;

Cappellini M D, Porter J B , Quebe-Fehling E, Pallaud C, Dieterle F,. Exploring the Clinical Utility of Renal Safety Biomarkers During Iron Chelation Therapy. Journal of Nephrology & Kidney Diseases. 2018; 1(2):119;

Mallat N., Mallat S., Musallam K., Taher A., Potential mechanisms for renal damage in beta-thalassemia, JNephrol 2013; 26(5): 821-828;

Kalousek I, Röselová P, Otevrelová P. NGALneutrophil gelatinase associated lipocalin in biochemistry, physiology and clinical praxis. Cas Lek Cesk, 2006, 145(5), 373-376;

Kjeldsen L, Cowland BJ, Borregaard N. Human neutrophil gelatinase-associated lipocalin and homologous proteins in rat and mouse – Biochim. Biophys. Acta, 2000, 1482(1-2), 272-283;

Devarajan P. Neutrophil gelatinase-associated lipocalin: a promising biomarker for human acute kidney injury. Biomarkers Med, 2010, 4(2), 265-280;

Mohkam M, Ghafari A. The Role of Urinary N-acetyl-beta-glucosaminidase in Diagnosis of Kidney Diseases. J Ped. Nephrology 2015;3(3):84-91;

Barton K. T, Kakajiwala А, Dietzen D. J., Goss C. W., Gu H., Dharnidharka V. R., Using the newer Kidney Disease: Improving Global Outcomes criteria, beta-2-microglobulin levels associate with severity of acute kidney injury, Clinical Kidney Journal, Volume 11, Issue 6, December 2018, Pages 797–802.




DOI: http://dx.doi.org/10.14748/an.v16i1.8471

Refbacks

About The Authors

Liliya Stoyanova
Clinic of Internal Medicine, St. Marina University Hospital, Medical University of Varna
Bulgaria

Svetla Staykova
Clinic of Nephrology and Dialysis, St. Marina University Hospital,Medical University Varna
Bulgaria

Triphon Chervenkov
Department of Medical Genetics, Faculty of Medicine, Medical University Varna
Bulgaria

Font Size


|