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Tubulopathy in Patients with Beta Thalassemia Major

Liliya Stoyanova, Svetla Staykova, Triphon Chervenkov


The iron overload and the development of secondary hemosiderosis in patients with β-thalassemia major lead to organ damages, including kidney disorders from an early childhood. Contemporary urinary markers such as neutrophil gelatinase-association lipocalin, β2-microglobulin, and N-acetyl-β-D-glucosaminidase could be a useful tool for clinicians in diagnosing early tubular lesions. The current study was performed in 44 patients with β-thalassemia major and 30 controls. All participants were tested for NGAL, β2-MG, and NAG in the first sample morning urine using the ELISA method. The results showed statistically significant difference in urinary NGAL between the two examined groups. This marker indicates very early damage to the proximal tubule before cell death occurs.


β-thalassemia major, β2-microglobulin (β2-MG), neutrophil gelatinase-associated lipocalin (NGAL), N-acetyl-beta-D-glucosaminidase (NAG)

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About The Authors

Liliya Stoyanova
Clinic of Internal Medicine, St. Marina University Hospital, Medical University of Varna

Svetla Staykova
Clinic of Nephrology and Dialysis, St. Marina University Hospital,Medical University Varna

Triphon Chervenkov
Department of Medical Genetics, Faculty of Medicine, Medical University Varna

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