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Evaluation of Dialysis Adequacy in Real Time by Ionic Dialysis—Reliability and Comparability of the Method

Diana Nenova

Abstract

Despite the progress made, the unsatisfactory results in the growing population of dialysis patients show that improved patient care is still not enough to increase survival and quality of life. The question of the need to improve hemodialysis therapies, which has been the subject of research and discussion for many years, remains relevant. Dialysis adequacy and the need for its quantitative measurement have been the subject of discussions since the dawn of hemodialysis treatment. It should be borne in mind that it is most often monitored once a month and by standards in some countries—every three months, and, based on the value obtained for the dialysis session, it is assumed that the result is representative of urea clearance of the entire dialysis. Measurement of dialysis adequacy is now achievable for each dialysis session without the need for additional blood tests and the results are available in real time using the ionic dialysis method, which registers the difference in sodium ionic conductivity at the inlet and outlet of the dialyzer of the dialysis dose delivered. A total of 128 measurements of the delivered dialysis dose by ionic dialysis and classical urea-kinetic modeling were performed at 32 chroniodialysis patients at the Clinic of Nephrology and Dialysis at the St. Marina University Hospital in Varna for a period of one year to assess the reliability and comparability of both methodologies, as well as the development of new therapeutic strategies with a view to improving the outcome.


Keywords

adequacy, dose, ionic dialysis, urea-kinetic modeling, sodium concentration

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References

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DOI: http://dx.doi.org/10.14748/an.v16i1.8474

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About The Author

Diana Nenova
Clinic of Nephrology and Dialysis, St. Marina University Hospital, Medical University of Varna Second Department of Internal Diseases, Faculty of Medicine, Medical University of Varna
Bulgaria

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