Coenzyme Q10: an innovative solution for treating chronic kidney disease and protecting heart health Coenzyme Q10 (CoQ10) is a fat-soluble, vitamin-like quinone found in cell membranes and mitochondria in both reduced (ubiquinol) and oxidized (ubiquinone) forms. Its concentration is high in organs with accelerated metabolism, such as the heart, kidneys, and liver, where it acts as an energy-carrying molecule. Factors that lead to reduced CoQ10 levels include age, genetic factors, medications, and cardiovascular and kidney diseases. Dysfunction in the mitochondrial respiratory chain, oxidative stress, and inflammation are involved in the pathogenesis of chronic kidney disease (CKD) and contribute to decreased plasma CoQ10 concentrations. CoQ10 reduces lipid peroxidation and inflammatory markers that cause kidney cell damage. Additionally, it positively affects cardiovascular parameters by lowering blood pressure and improving endothelial function, thereby reducingthe risk of cardiovascular incidents. Its therapeutic use in CKD patients offers a dual mechanism of action: reducing oxidative stress and inflammation and improving cardiovascular health. This makes CoQ10 a promising addition to therapeutic strategies for treating chronic kidney disease and preventing cardiovascular complications.
C.M. Rhee, C.P. Kovesdy; Epidemiology: spotlight on CKD deaths-increasing mortality worldwide; Nat Rev Nephrol, 11 (2015), pp. 199-200
Delacruz CS, Kang MJ. Mitochondrial dysfunction and damage associated molecular patterns in chronic inflammatory diseases. Mitochondrion; 41: 37- 44.
DiNicolantonio JJ, Bhutani J, McCarty MF, et al.. Coenzyme Q10 for the treatment of heart
failure: a review of the literature. Open Heart 2015;2:e000326 10.1136/openhrt-2015-000326
Fan, L.; Feng, Y.; Chen, G.C.; Qin, L.Q.; Fu, C.L.; Chen, L.H. Effects of coenzyme Q10 supplementation on inflammatory markers: A systematic review and meta-analysis of randomized controlled trials. Pharmacol. Res. 2017, 119, 128–136.
Gazdíková K, Gvozdjáková A, Kucharská J, et al.. Oxidative stress and plasma concentrations of coenzyme Q10, alpha-tocopherol, and betacarotene in patients with a mild to moderate decrease of kidney function. Nephron 2001;88:285 10.1159/000046007
Granata S, Gassa A, Tomei P, Lupo A, Zaza G. Mitochondria: a new therapeutic target in CKD. Nutr Metab 2015;49: doi: 10.1186/ s12986-015-0044
Granata S, Zaza G, Simone S, et al. Mitochondrial dysregulation and oxidative stress in patients with CKD. BMC Genomics 2009; 10: doi: 10.1186/1471- 2164-10-388.
Grazioli S, Pugia J. Mitochondrial damage associated molecular patterns: from inflammatory signalling to human diseases. Front Immunol; 9:832; 2018.
Hargreaves, I.P. CoQ10 as a therapy for mitochondrial disease. Int. J. Biochem. Cell Biol. 2014, 49, 105–111.
Hargreaves, IP, Mantle, D and Milford, D (2019) Chronic kidney disease and coenzyme Q10 supplementation. Journal of Kidney Care, 4 (2). pp. 82-90. ISSN 2397-9534
Hargreaves IP. Ubiquinone: cholesterol‘s reclusive cousin. Ann Clin Biochem. 2003 May
K.J. Jager, C. Kovesdy, R. Langham, et al.; A single number for advocacy and communicationworldwide more than 850 million individuals have kidney diseases; Kidney Int, 96 (2019), pp. 1048-1050
GBD Mortality Causes of Death Collaborators; Global, regional, and national age-sex specific allcause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the 14 Coenzyme Q10: Иновативно решение за лечение на хронично бъбречно заболяване и сърдечна протекция Global Burden of Disease Study 2013; Lancet, 385 (2015), pp. 117-171
Mantle D, Hargreaves I. Coenzyme Q10 and Degenerative Disorders Affecting Longevity: An Overview. Antioxidants. 2019; 8(2):44.
Mehmetoglu I, Yerlikaya FH, Kurban S, et al.. Oxidative stress markers in hemodialysis and peritoneal dialysis patients, including coenzyme Q10 and ischemia-modified albumin. Int J Artif Organs 2012;35:226–32. 10.5301/ijao.5000078
Meyer A, Laverny G, Bernardi L, Charles AL, Alsaleh G, Pottecher J et al. Mitochondria: an organelle of bacterial origin controlling inflammation. Front Immunol; 9:536, 2018.
Mutsaers HA, Wilmer MJ, Jawnsen J et al. Uremic toxins inhibit renal metabolic capacity through interference with glucuronidation and mitochondrial respiration. Biochim Biophys Acta 2013; 1832: 142-150.
Navas P, Villalba JM, de Cabo R. The importance of plasma membrane coenzyme Q in aging and stress responses. Mitochondrion.2007; 7S: S34-S40.
N.R. Hill, S.T. Fatoba, J.L. Oke, et al.; Global prevalence of chronic kidney disease - a systematic review and meta-analysis; PLoS One, 11 (2016), Article e0158765
Rivara MB, Yeung CK, Robinson-Cohen C, et al.. Effect of Coenzyme Q10 on Biomarkers of Oxidative Stress and Cardiac Function in Hemodialysis Patients: The CoQ10 Biomarker Trial. Am J Kidney Dis 2017;69:389–99. 10.1053/j. ajkd.2016.08.041
R. Saran, B. Robinson, K.C. Abbott, et al.; US Renal Data System 2019 annual data report: epidemiology of kidney disease in the United States; Am J Kidney Dis, 75 (2020), pp. A6-A7
Singh, R. B., Khanna, H. K., & Niaz, M. A. (2000). Randomized, Double-blind Placebo-controlled Trial of Coenzyme Q10 in Chronic Renal Failure: Discovery of a New Role. Journal of Nutritional & Environmental Medicine, 10(4), 281–288.
Stepien KM, Heaton R, Rankin S, et al. Evidence of oxidative stress and secondary mitochondrial dysfunction in metabolic and non-metabolic disorders. J Clin Med 2017; 6: doi: 10.3390/ jcm6070071.
Turunen M, Olsson J, Dallner G. Metabolism and function of coenzyme Q. Biochimica et Biophysica Acta (BBA) Biomembranes. 2004; 1660(1–2): 171-199.
Weber C et al.The CoQ10 content of the average Danish diet. Int J Vitam Nutr Res 1997; 67: 123-129.
Wipf Р, A. Polyzos, C. Mcmurray; A Double-Pronged Sword: XJB-5-131 Is a Suppressor of Somatic Instability and Toxicity in Huntington’s Disease; December 2021; Journal of Huntington‘s disease 11(1):1-1311(1):1-13)
Xiaofeng Zhang, PhD,a Zhaofeng Shi, MD,b Qian Liu, MD,c Haohao Quan, BD,d and Xiaohong Cheng, PhDa, Monitoring Editor: Liang-Jun Yan. Effects of coenzyme Q10 intervention on diabetic kidney disease. Medicine (Baltimore). 2019 Jun; 98(24): e15850.12.
Zhai, J.; Bo, Y.; Lu, Y.; Liu, C.; Zhang, L. Effects of Coenzyme Q10 on Markers of Inflammation: A Systematic Review and Meta- Analysis. PLoS ONE 2017, 12, e0170172.