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Bulgarian Review of Ophthalmology

Central serous chorioretinopathy - microstructural characteristics of pathological changes

Elitsa Hristova, Zhana Simova, Zornitsa Zlatarova


Introduction: Central serous chorioretinopathy (CSCR) is a disease characterized by serous detachment of the neurosensory retina and/or retinal pigment epithelium (RPE), often affecting the macula and associated with fluid leakage through the RPE or Bruch`s membrane into the subretinal space.

Aim: The aim of this article is to present a quantitative and qualitative assessment of changes in the retinal thickness, volume and microstructure in patients with central serous chorioretinopathy (CSCR) using optical coherence tomography (OCT).

Methods: The study included 102 eyes of 82 subjects who were divided into two main groups - healthy eyes without systemic or ocular disease and a group with CSCR. All subjects underwent a complete ophthalmologic examination and OCT. The group with pathological retinal changes was examined also with fluorescein angiography (FA). Statistical analyses were carried out using SPSS v. 19.

Results: The group with CSCR consisted of 41 subjects (51 eyes; 32 - right ones, 19 - left ones) at a mean age of 45.02±8.19 years (30 - 63 years) - 31 (75.6%) men and 10 (24.4%) women. The median follow-up period was 3 months (1-24 months). For this period best-corrected visual acuity and retinal thickness and volume were assessed on the first, second and last visit. OCT scans were evaluated for changes of the retinal pigment epithelium (RPE) (51%), serous retinal detachment (60.8%), pigment epithelium detachment (PED) (52.9%), subretinal (15.7%) or intraretinal (13.7%) deposits, bridging tissue connecting RPE and the neurosensory retina (3.9%), and RPE protrusion (15.7%).

Conclusion: Optical coherence tomography facilitated diagnosis of CSCR changes like serous retinal detachment and PED. High OCT image resolution improved the visibility of very small retinal changes, which could easily be missed with conventional indirect ophthalmoscopy.


central serous chorioretinopathy; OCT

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About The Authors

Elitsa Hristova
Medical University of Varna

Department of Ophthalmology and Visual Science, Faculty of Medicine

Zhana Simova
Medical University of Varna

Department of Ophthalmology and Visual Science, Faculty of Medicine

Zornitsa Zlatarova
Medical University of Varna

Department of Ophthalmology and Visual Science, Faculty of Medicine