Introduction:
Keratoplasty is one of the most common tissue transplants. The survival rate in these cases is about 57% for a 5-year period and 11.1%—for a 12-year period. The primary diagnosis also has an influence.
Aim:
The aim of this article is to present the results of penetrating keratoplasty in reoperation patients over a 10-year period.
Material and Methods:
A retrospective clinical study was conducted in which 31 patients (33 eyes) with repeat keratoplasty were followed up and analyzed. The average period between the primary keratoplasty and the first repeat keratoplasty was 19 months. All patients underwent penetrating keratoplasty.
Results:
Distributed by gender, 21 (67.74%) of the patients were male and 10 (32.26%) were female. At discharge from the hospital, the transplant was transparent in 80–84% of cases. According to the primary indication for keratoplasty, the percentage of patients with bullous keratopathy and corneal dystrophy was the highest. The percentage of patients with visual acuity was the highest—0.05–0.09. No statistically significant difference was found in graft survival depending on the number of reoperations and the primary indication for keratoplasty.
Conclusion:
Repeat keratoplasty is the only option for some improvement in vision, despite the high risk.
Muraine M, Sanchez C, Watt L, Retout A, Brasseur G. Long-term results of penetrating keratoplasty. A 10-year-plus retrospective study. Graefes Arch Clin Exp Ophthalmol. 2003;241(7):571-6. doi: 10.1007/s00417-003-0691-z.
Beckingsale P, Mavrikakis I, Al-Yousuf N, Mavrikakis E, Daya SM. Penetrating keratoplasty: outcomes from a corneal unit compared to national data. Br J Ophthalmol. 2006;90(6):728-31. doi: 10.1136/bjo.2005.086272.
Al-Mezaine H, Wagoner MD; King Khaled Eye Specialist Hospital Cornea Transplant Study Group. Repeat penetrating keratoplasty: indications, graft survival, and visual outcome. Br J Ophthalmol. 2006;90(3):324-7. doi: 10.1136/bjo.2005.079624.
Al-Yousuf N, Mavrikakis I, Mavrikakis E, Daya SM. Penetrating keratoplasty: indications over a 10-year period. Br J Ophthalmol. 2004;88(8):998-1001. doi: 10.1136/bjo.2003.031948.
Roberts HW, de Benito-Llopis L. Comparison of repeat penetrating keratoplasty, DSAEK and DMEK for the management of endothelial failure of previous PK. Eye (Lond). 2023;37(17):3596-601. doi: 10.1038/s41433-023-02561-5.
Seitz B, Daas L, Wykrota AA, Flockerzi E, Suffo S. Graft Failure after PKP and DMEK: What is the Best Option? Klinische Monatsblatter fur Augenheilkunde. 2022;239(6):775-785. doi: 10.1055/a-1774-4862.
Steindor FA, Menzel-Severing J, Borrelli M, Schrader S, Geerling G. DMEK after penetrating keratoplasty: cohort with DMEK grafts and descemetorhexis larger than full-thickness graft. Graefes Arch Clin Exp Ophthalmol. 2022;260(9):2933-9. doi: 10.1007/s00417-022-05641-6.
Maguire MG, Stark WJ, Gottsch JD, Stulting RD, Sugar A, Fink NE, Schwartz A. Risk factors for corneal graft failure and rejection in the collaborative corneal transplantation studies. Collaborative Corneal Transplantation Studies Research Group. Ophthalmology. 1994;101(9):1536-47. doi: 10.1016/s0161-6420(94)31138-9.
Kirkness CM, Ficker LA, Steele AD, Rice NS. The success of penetrating keratoplasty for keratoconus. Eye (Lond). 1990;4 (Pt 5):673-88. doi: 10.1038/eye.1990.95.
Bersudsky V, Blum-Hareuveni T, Rehany U, Rumelt S. The profile of repeated corneal transplantation. Ophthalmology. 2001;108(3):461-9. doi: 10.1016/s0161-6420(00)00544-3.
Debourdeau E, Builles N, Couderc G, Boulhic J, Chamard C, Villain M, et al. Risk factors of rejection after penetrating keratoplasty: a retrospective monocentric study. Graefes Arch Clin Exp Ophthalmol. 2022;260(11):3627-38. doi: 10.1007/s00417-022-05691-w.
Sapkota J, Bajracharya L, Gurung R, Rana RS. Indications and Outcomes of Repeat Keratoplasty for Graft Failure at a Tertiary Eye Care Center in Nepal. Nepal J Ophthalmol. 2023;15(29):85-91. doi: 10.3126/nepjoph.v15i1.54803.
Chotikavanich S, Prabhasawat P, Satjapakasit O. Ten-Year Survival of Optical Penetrating Keratoplasty and Risk Factors for Graft Failure in Thai Patients. J Med Assoc Thai. 2020;103(9):883. doi: 10.35755/jmedassocthai.2020.09.8667
Park DB, Situ B, Nguyen A. Indications and outcomes of repeat keratoplasty at a major safety net hospital. Invest Ophthalmol Vis Sci. 2020;61(7):3581.
Email this article (Login required) 
