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Expression Of Micro-Ribonucleic Acid 451 When Used With Chronic Inflammatory Bowel Disease

Antonia Atanassova



MicroRNA-451 was first identified more than a decade ago in human pituitary tissue. There is growing evidence of the important role of miR-451 in immune-mediated diseases. Chronic inflammatory bowel disease (IBD) is an example of an immune-mediated disease with unclear pathogenesis and difficult to follow activity due to the diverse clinical picture. Therefore, we aimed to determine the role of miR-451 expression in patients with Crohn's disease (CD) and ulcerative colitis (UC).

Material and Methods:

A total of 35 consecutive patients with UC, 35 patients with CD, and a control group of 30 healthy subjects were included. In all of them, the serum expression of miR-451 was examined by reverse transcriptase—quantitative real-time polymerase chain reaction PCR (RT-qPCR). The results were statistically processed with SPSS v. 20.0 for Windows, using variation, variance, comparative, correlation analysis, and ROC curve analysis.


Circulating levels of microRNA-451 in patients with IBD are associated with active disease, intestinal localization, vitamin deficiency. Vitamins B12 and D3 and corticosteroid treatment are recommended.


Due to the limited number of IBD studies, extensive cohort studies are needed to validate the established results.


microRNA-451, Crohn's disease, ulcerative colitis, expression

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