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Izvestia Journal of the Union of Scientists - Varna. Medicine and Ecology Series

Whipple`s disease - the challenge of the clinical imitator

Diana Todorova Gancheva-Tomova


Whipple`s disease is a rare systemic infectious disease caused by the bacterium Tropheryma whipplei. It affects many organs and systems. The disease is still difficult to diagnose because of the variety of clinical symptoms and the possible long period between the first uncharacteristic signs and the complete clinical picture of the disease. Because the clinical symptoms of the disease are nonspecific, the diagnosis is still a challenge for the clinician. The outcome is fatal in the absence or failure of antibiotic treatment. We present a brief review of the literature on the clinical picture, the diagnostic possibilities, and the treatment of Whipple's disease.


Whipple`s disease, clinical manifestations, diagnosis, treatment

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