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Journal of the Union of Scientists - Varna. Medicine and Ecology Series

Bacterial pulmonary colonization with Pseudomonas aeruginosa in cystic fibrosis patients

Margarita Nikolova, Yoana Dyankova, Ivan Hristov, Miglena Georgieva


Introduction: Cystic fibrosis (CF) is the most common life-limiting autosomal recessive condition in Caucasians. Lung damage is the main determinant of morbidity and mortality. The most important factor for chronic lung infection is the colonization with Pseudomonas aeruginosa.

Aim: Understanding the nature of the infection with Pseudomonas aeruginosa and its factors of virulence and compiling statistics on age-related bacterial pulmonary colonization in patients with cystic fibrosis in Expert Center-Varna.

Methods: Review of the medical literature and microbiological examination (sputum specimen, oropharyngeal swabs, BAL) of patients with cystic fibrosis at the Expert Center-Varna.

Results: With increasing age of the patient with cystic fibrosis there has also been an increase in the rate of pulmonary colonization with Pseudomonas aeruginosa - up to 85% in patients over 18 years of age.

Conclusion: Pseudomonas aeruginosa is largely responsible for morbidity and mortality in chronically infected cystic fibrosis patients. Therefore, prevention and early diagnosis are vital to the prognosis of these patients.


cystic fibrosis, Pseudomonas aeruginosa, lung infection, colonization, diagnosis

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