Scientific Online Resource System

Izvestia Journal of the Union of Scientists - Varna. Medicine and Ecology Series

The role of RIP3 in prostate cancer

Kalin Kalchev


The process of necroptosis and its role in tumors with different locations have been studied in detail in the last few years. However, not much is known about its significance for prostate cancer, perhaps because necrosis is a rare morphological phenomenon in the prostate. In this study, we quantify the expression of the necroptosis marker RIP3 in tumor and non-tumor glands in cases of prostate cancer and analyze its correlation to some morphological parameters and patients' survival rate.


RIP3; necroptosis; prostate cancer

Full Text


Basit F, Cristofanon S, Fulda S. Obatoclax (GX15-070) triggers necroptosis by promoting the assembly of the necrosome on autophagosomal membranes. Cell Death Differ. 2013. doi: 10.1038/cdd.2013.45

Bray K, Mathew R, Lau A, Kamphorst JJ, Fan J, Chen J, Chen HY, Ghavami A, Stein M, DiPaola RS, et al. Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition. PLoS ONE. 2012. 7: e41831

Degterev A, Hitomi J, Germscheid1 M, Ch’en IL, Korkina1 O, Teng X, Abbott D, Cuny GD, Yuan C, Wagner G, Hedrick SM, Gerber SA, Lugovskoy A, Yuan J. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nature chemical biology, 2008, 4/5: 313-321

Fu D, Jordan JJ, Samson LD. Human ALKBH7 is required for alkylation and oxidation-induced programmed necrosis. Genes Dev. 2013. 27: 1089–1100

Galuzzi L, Kroemer G. Necroptosis: A Specialized Pathway of Programmed Necrosis. Cell, 2008. 135: 1161-1163

Hanahan D, Weinberg RA. Hallmarks of cancer: The next generation. Cell, 2011, 144: 646–674

Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflammation. Nature, 2008. 454: 436–444

Moriwaki K, Ka-Ming Chan F. RIP3: a molecular switch for necrosis and inflammation. Genes & Development. 2014. 27:1640–1649

Pfeffer C, Singh A. Apoptosis: A Target for Anticancer. Therapy Int. J. Mol. Sci. 2018. 19, 448

Sosna J, Voigt S, Mathieu S, Lange A, Thon L, Davarnia P, Herdegen T, Linkermann A, Rittger A, Chan FK, et al. TNF-induced necroptosis and PARP-1-mediated necrosis represent distinct routes to programmed necrotic cell death. Cell Mol Life Sci. 2013. doi: 10.1007/s00018-013-1381-6

Tenev T, Bianchi K, Darding M, Broemer M, Langlais C, Wallberg F, Zachariou A, Lopez J, MacFarlane M, Cain K, et al. The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs. Mol Cell. 2011. 43: 432–448

Vanlangenakker N, Vanden Berghe T, Vandenabeele P. Many stimuli pull the necrotic trigger, an overview. Cell Death and Differentiation. 2012. 19, 75–86

Zong WX, Ditsworth D, Bauer DE, Wang ZQ, Thompson CB. Alkylating DNA damage stimulates a regulated form of necrotic cell death. Genes Dev (2004) 18: 1272–1282



Font Size