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Journal of the Union of Scientists - Varna. Medicine and Ecology Series

At the border of inflammation and fibrosis - serum expression of miR 29 in patients with inflammatory bowel disease

Antonia Atanassova, Maria Teneva


Introduction: Recently, the expression of micro ribonucleic acids (microRNAs) in peripheral blood and tissues in patients with chronic inflammatory bowel disease (IBD) has been studied as a biomarker for diagnosis and monitoring of activity.

Aim: The aim of this study is to evaluate the correlation between serum microribonucleic acid 29 (miR-29) expression and different clinical parameters: activity, severity and extent of disease in IBD patients.

Materials and Methods: Serum miR-29 expression was tested in 70 patients with IBD (35 with ulcerative colitis (UC), 35 patients with Crohn's disease (CD)) and 30 healthy control subjects through reverse transcriptase and real-time quantitative PCR (RT-qPCR).

Results: The group of patients showed a mean serum miR-29 expression of 1.69 for CD, 1.23 for UC and 1.07 for the control group with a significant difference in expression between the groups.

Conclusion: There is a significant relation between increased serum miR-29 expression and disease activity, severity and extent in patients with UC.


miR-29, ulcerative colitis, Crohn's disease, chronic inflammatory bowel disease

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