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Izvestia Journal of the Union of Scientists - Varna. Medicine and Ecology Series

The role of platelet concentrates in oral surgery—a literature review

Madlen Ali, Georgi Papanchev

Abstract

Introduction: Numerous studies examine the application of biomaterials in regenerative medicine. Platelet concentrates, derived from centrifuged autologous blood, have gained significant attention as biomaterials in the engineering of oral soft and hard tissues. 

Materials and Methods: This study systematizes the application of platelet concentrates in the field of oral surgery. A literature review was conducted by examining peer-reviewed scientific publications available in the Google Scholar, PubMed, and ResearchGate databases. A total of 36 articles published in the last 5 years were reviewed, of which 13 were selected as primary sources. 

Results: The application of platelet concentrates in oral surgery is extensive. Their combination with other biomaterials or stem cells represents a modern concept aimed at achieving synergy, expanding their fields of application, and overcoming limitations. The high concentration of growth factors plays a significant role in their broad applicability and highlights one of their main qualities—accelerating tissue regeneration. 

Discussion: The potential for the application of platelet concentrates in daily surgical practice is significant. They possess three main characteristics: acting as a scaffold for the adhesion of new cells, serving as a source of growth factors, and containing vital cells, all of which contribute to their positive impact on damaged tissue. 

Conclusion: Many studies highlight the importance of platelet concentrates in tissue healing and regeneration, confirming their benefits. However, their role in complex clinical cases remains debated, and further long-term research is needed to establish them as a predictable biomaterial.


Keywords

platelet concentrates; tissue engineering; platelet rich plasma; platelet rich fibrin; platelet-derived growth factors

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DOI: http://dx.doi.org/10.14748/isuvsme.v29i2.9969

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