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Journal of Varna Medical College

Immunomodulating and antitumor effect of Agaricus blazei, Coriolus versicolor, Ganoderma lucidum, Grifola frondosa

Antoaneta Tsvetkova, Antonia Hristova, Dimana Dimitrova, Desislava Aleksandrova, Silvia Mihaylova, Momchil Lambev

Abstract

The curative use of mushrooms has a long tradition in Asian countries, whereas their use in the Western countries has gradually increased in recent decades. Some of the studied mushrooms are among the most powerful stimulators and modulators of the immune system. Their healing properties are highly valued and subject to many studies. They lower cholesterol, help reduce weight loss, and help control diabetes. Their benefits are thoroughly researched and documented. Most attention is attracted by their anticancer properties. There are many mushrooms with powerful anticancer properties, but the best results are obtained with the use of preparations containing extracts from more than one type of fungus. Some studies have shown that polysaccharide is the main component with an antitumor effect.

The molecular weight, branching rate, number of substitutions as well as ultrastructure, including the presence of single and triple helices significantly affect the biological activities of beta-glucans. Higher antitumor activity appears to be correlated with higher molecular weight, lower branching, and greater water-soluble beta-glucans.


Keywords

antitumor activity, mushroom extract, immunomodulator, adjuvant therapy, beta-glucan

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