Chronic rhinosinusitis is a common disease. Some authors accept the leading role of Dematiaceous family fungi in its pathogenesis. Eosinophils are major actors in the immune reaction. The aim of the study is to determine the role of Dematiaccous family fungi and Aspergillus in pathogenesis of CRS with nasal polyposis.
Material and methods: In the course of 4 months we examined 34 patients (20 females and 14 males) (40-65 year old) with chronic rhinosinusitis (CRS) with nasal polyposis and 20 (12 females and 8 males) (40-65 year old)controls. Nasal secret was taken from all patients and controls for cytological exam. Skin prick test and slgG to fungal allergens (Aspergillus, Altcmaria, Fusarium, Rhizopus, Penicillium H Mucor) was performed with all patients and healthy controls.
Results: Cytologic examination of nasal smear showed: presence of fungal elements(hyphies) in 8 controls (80%) and lack of eosinophils in all control subjects, while 24 patients had fungal elements (70,58%) and eosinophils in 27 (79,4%) of them. Skin prick tests were positive to one or several fungal types in 4 (11,8%) of patients with poliposis and none of the control group. Examination of sera for specific IgG was positive in all groups. In the control group the titre of specific antibodies was 2,5-40 µg/ml while in the patients group the titre was significantly higher (> 40 µg/ml) - in 28 (82,4%) patients respectively.
Discussion: The aim of this study is to determine the role of fungi in pathogenesis of CRS with poliposis.
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