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International Bulletin of Otorhinolaryngology

Analysis of mucociliary transport of the maxillary sinus mucosa after surgical trauma and in the presence of chronic inflammation

Gergana Slivovska


Background: The membrane of the maxillary sinus actively participates in the protective function of the upper respiratory tract through the mucociliary transport carried out by its ciliated epithelium. The presence of pathological changes in the sinus cavity directly affects the ability of the Schneider’s membrane to effectively perform its drainage function. The activity of mucociliary transport is reduced and the time required for the cleansing activity of the maxillary sinus is increased.
Methods: In the study we are introducing, a total of 20 patients were included, divided into two groups. Patients were scheduled for local maxillary sinus plastic surgeries. Group 1 included patients in whom we did not find a change in the thickness of the mucosa of the maxillary sinus on CBCT. In group two we selected patients with radiological data for thickened mucosa of the maxillary sinus between 5 mm and 7 mm. Before closing the communication, we placed a saccharin granule in the maxillary sinus. We assessed the activity of mucociliary transport by measuring the time for which patients registered a sweet taste in their mouth.
Results: In all of the 20 patients, we found prolonged drainage function of the maxillary sinus mucosa. For group 1, this time was recorded in the interval from 115 minutes to 238 minutes (average 137 minutes). In group 2, the time reported was between 210 and 345 minutes (average value 270.75 minutes).
Conclusions: Based on the results obtained, we can conclude that surgical trauma and chronic inflammation of the membrane of the maxillary sinus affect the efficiency of the mucociliary transport.


Mucociliary transport, Maxillary sinus mucosa, Chronic maxillary sinuitis

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Национален Консенсус за диагностика и медикаментозно лечение на острия бактериален риносинуит – НАЦИОНАЛЕН КОНСЕНСУС ЗА ДИАГНОСТИКА И МЕДИКАМЕНТОЗНО ЛЕЧЕНИЕ НА ОСТРИЯ БАКТЕРИАЛЕН РИНОСИНУИТ, БЪЛГАРСКО СДРУЖЕНИЕ ПО РИНОЛОГИЯ 2007 г.

Todorov, S., Todorov, I. (2010). Practical Instructions for Diagnosis and Treatment of the Acute Bacterial Sinuitis in Adults. International Bulletin of Otorhinolaryngology, 6(2), 5-8.

Европейски консенсус за риносинуити и носна полипоза, 2020 – преводно българско издание, ISBN 978-619-91274-2-1, 2021г.

Бенчев, Р., К. Джамбазов, В. Павлов, Д. Вичева, В. Цветков, и др. Съвременни концепции за консервативното лечение на хроничния риносинуит. – Пловдив : Алекс Делта Адвъртайзинг, 2012, 72 с.

Трайкова, Н., К. Джамбазов, И. Йовчев. Ролята на компютъртомографското изследване при диагностиката на заболяванията на носа и околоносните кухини. // Оториноларингология (София), 4, 2000, 2, 42-51.

Andrew Whyte, Rudolf Boeddinghaus. The maxillary sinus: physiology, development and imaging anatomy Dentomaxillofac Radiol. 2019 Dec;48(8):20190205. doi: 10.1259/dmfr.20190205. Epub 2019 Aug 13.

A Whyte 1, R Boeddinghaus Imaging of odontogenic sinusitis Clin Radiol. 2019 Jul;74(7):503-516. doi: 10.1016/j.crad.2019.02.012. Epub 2019 Mar 27.

John L. Sobiesk, Sunil Munakomi Anatomy, Head and Neck, Nasal Cavity In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan. 2021 Jul 26.

Cohen NA. Sinonasal mucociliary clearance in health and disease. Ann Otol Rhinol Laryngol 2006; 115(9_suppl): 20–6. doi: 10.1177/00034894061150S904 [PubMed] [CrossRef] [Google Scholar]

Beule AG. Physiology and pathophysiology of respiratory mucosa of the nose and the paranasal sinuses. GMS Curr Top Otorhinolaryngol Head Neck Surg 2011; 2010. [PMC free article] [PubMed] [Google Scholar]

Anil Kumar S Harugop 1, B Deepthi 1, Suhasini Hanumaiah 1, S Puneeth Nayak 1, N R Ankale 1, Shama A Bellad 1Does Endoscopic Sinus Surgery (ESS) Retrieve Mucociliary Clearance of Maxillary Sinus: Prospective Study at a Tertiary Care Hospital Indian J Otolaryngol Head Neck Surg. 2019 Nov;71(Suppl 3):2210-2213. doi: 10.1007/s12070-019-01666-2. Epub 2019 Apr 25.

Mangal Singh 1, Manish Chandra, S C Gupta, Devashish Sharma. Role of measurement of nasal mucociliary clearance by saccharine test as a yard stick of success of functional endoscopic sinus surgery Indian J Otolaryngol Head Neck Surg. 2010 Sep;62(3):289-95. doi: 10.1007/s12070-010-0074-9. Epub 2010 Oct 12.

HyunJun Lee, Jong Seung Kim Endoscopic findings of dental implant found in the infundibulum showing the mucociliary clearance of the maxillary sinus Ear Nose Throat J. 2022 Jan 2;1455613211062454. doi: 10.1177/01455613211062454. Online ahead of print.

Anil Kumar S Harugop, B Deepthi, Suhasini Hanumaiah, S Puneeth Nayak, N R Ankale, Shama A Bellad Does Endoscopic Sinus Surgery (ESS) Retrieve Mucociliary Clearance of Maxillary Sinus: Prospective Study at a Tertiary Care Hospital Indian J Otolaryngol Head Neck Surg. 2019 Nov;71(Suppl 3):2210-2213. doi: 10.1007/s12070-019-01666-2. Epub 2019 Apr 25.

Mohsen Naraghi, Neda Baghbanian, Melorina Moharari, Amene Saghazadeh Improvement of sinonasal mucociliary function by endoscopic sinus surgery in patients with chronic rhinosinusitis Am J Otolaryngol. Nov-Dec 2018;39(6):707-710. doi: 10.1016/j.amjoto.2018.07.019. Epub 2018 Jul 25.

Argyro J Bizaki, Jura Numminen, Rami Taulu, Markus Rautiainen A Controlled, Randomized Clinical Study on the Impact of Treatment on Antral Mucociliary Clearance: Uncinectomy Versus Balloon Sinuplasty Ann Otol Rhinol Laryngol. 2016 May;125(5):408-14. doi: 10.1177/0003489415618676. Epub 2015 Nov 26.

Pasquale Caponnetto, Rosalia Emma, Francesca Benfatto, Salvatore Ferlito, Alessandro Gulino, Antonino Maniaci, Jerome R Lechien, Angelo Ingrassia, Salvatore Cocuzza, Riccardo Polosa Saccharin test: Methodological validation and systematic review of the literature Ear Nose Throat J. 2021 Dec 16;1455613211064044. doi: 10.1177/01455613211064044. Online ahead of print.

Fernanda Rodrigues, Ana Paula Freire, Juliana Uzeloto, Rafaella Xavier, Juliana Ito, Marceli Rocha, Renata Calciolari, Dionei Ramos, Ercy Ramos Particularities and Clinical Applicability of Saccharin Transit Time Test Int Arch Otorhinolaryngol. 2019 Apr;23(2):229-240. doi: 10.1055/s-0038-1676116. Epub 2019 Feb 15.

Seyhan Dülger, Önder Akdeniz, Fevzi Solmaz, Özlem Şengören Dikiş, Tekin Yildiz 1Evaluation of nasal mucociliary clearance using saccharin test in smokers: A prospective study Clin Respir J. 2018 Apr;12(4):1706-1710.doi: 10.1111/crj.12733. Epub 2017 Dec 4.

Hilal Yücel, Serpil Ergülü Eşmen Evaluation of nasal mucociliary clearance by saccharine test in rheumatoid arthritis Braz J Otorhinolaryngol. 2021 Oct 17;S1808-8694(21)00157-9. doi: 10.1016/j.bjorl.2021.08.005. Online ahead of print.

I B Popov, D A Shcherbakov, The Tyryk B , T A Aleksanyan [New approach to treatment of polypous rhinosinusitis] Vestn Otorinolaringol. 2020;85(3):48-51. doi: 10.17116/otorino20208503148.

Seyhan Dülger, Çağla Çapkur, Sündüs Gençay, Süay Özmen, Fevzi Solmaz, Özlem Şengören Dikiş, Tekin Yıldız The relationship between nasal mucociliary clearance time and the degree of smoking dependence in smokers with obstructive sleep apnea syndrome Adv Respir Med. 2021;89(4):353-358. doi: 10.5603/ARM.a2021.0069. Epub 2021 Jul 16.

S Inanli 1, A Tutkun, C Batman, I Okar, C Uneri, M A Sehitoğlu The effect of endoscopic sinus surgery on mucociliary activity and healing of maxillary sinus mucosa Rhinology. 2000 Sep;38(3):120-3.

Pedro Plaza Valía, Francisco Carrión Valero, Julio Marín Pardo, Daniel Bautista Rentero, Carmen González MonteArch Bronconeumol [Saccharin test for the study of mucociliary clearance: reference values for a Spanish population]. 2008 Oct;44(10):540-5.

L Brondeel, R Sönstabö, P Clement, W van Ryckeghem, M van den Broek Value of the Tc99m particle test and the saccharin test in mucociliary examinations Rhinology. 1983 Jun;21(2):135-42.

I Andersen, P Camner, P L Jensen, K Philipson, D F Proctor. Nasal clearance in monozygotic twins Am Rev Respir Dis. 1974 Sep;110(3):301-5. doi: 10.1164/arrd.1974.110.3.301.

S M Birdi, S Singh, A Singh. Mucociliary clearance in chronic sinusitis Indian J Otolaryngol Head Neck Surg. 1998 Jan;50(1):15-9. doi: 10.1007/BF02996761.

Stammberger H. Functional endoscopic sinus surgery Ed. Mosby, Year Book, 1991.



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