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Acute necrotizing encephalopathy with fatal outcome in a patient with fulminant influenza A (H1N1) infection

Yana Deyanova, Darina Krumova, Darina Zlatkova, Mergyul Halilova, Miryana Kondakova, Jivka Demireva-Kalcheva, Violeta Iotova

Abstract

Influenza is a viral infection that spreads annually as an epidemic, and every few years as a pandemic. In most cases, the infection occurs with mild symptoms. However, severe illness with serious complications is possible, as certain subtypes of the virus, such as H1N1, are associated with a higher risk of more severe course of the infection. Neurological involvement, although rarely observed during acute influenza infection, is one of the serious complications with a risk of permanent damage or death. Children belong to the risk groups for whom vaccination after 6 months of age is of particular importance, both for limiting the spread of the infection and for preventing complications. We present a clinical case of a 6-year-old child with a fulminant course of infection with influenza A, subtype H1N1, with severe neurological involvement and fatal outcome.


Keywords

influenza, H1N1, pediatric, acute necrotizing encephalopathy

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References

Gaitonde DY, Moore FC, Morgan MK. Influenza: Diagnosis and Treatment. Am Fam Physician. 2019 Dec 15;100(12):751-758.

Peteranderl C, Herold S, Schmoldt C. Human Influenza Virus Infections. Semin Respir Crit Care Med. 2016 Aug;37(4):487-500. doi: 10.1055/s-0036-1584801.

Nypaver C, Dehlinger C, Carter C. Influenza and Influenza Vaccine: A Review. J Midwifery Womens Health. 2021 Jan;66(1):45-53. doi: 10.1111/jmwh.13203.

Wolf RM, Antoon JW. Influenza in Children and Adolescents: Epidemiology, Management, and Prevention. Pediatr Rev. 2023 Nov 1;44(11):605-617. doi: 10.1542/pir.2023-005962.

Świerczyńska M, Mirowska-Guzel DM, Pindelska E. Antiviral Drugs in Influenza. Int J Environ Res Public Health. 2022 Mar 4;19(5):3018. doi: 10.3390/ijerph19053018.

Sullivan SJ, Jacobson RM, Dowdle WR, Poland GA. 2009 H1N1 influenza. Mayo Clin Proc. 2010 Jan;85(1):64-76. doi: 10.4065/mcp.2009.0588.

Nayak J, Hoy G, Gordon A. Influenza in Children. Cold Spring Harb Perspect Med. 2021 Jan 4;11(1):a038430. doi: 10.1101/cshperspect.a038430.

Zhang L, van der Hoek W, Krafft T, Pilot E, Asten LV, Lin G, Wu S, Duan W, Yang P, Wang Q. Influenza vaccine effectiveness estimates against influenza A(H3N2) and A(H1N1) pdm09 among children during school-based outbreaks in the 2016-2017 season in Beijing, China. Hum Vaccin Immunother. 2020 Apr 2;16(4):816-822. doi: 10.1080/21645515.2019.1677438.

Surana P, Tang S, McDougall M, et al. Neurological complications of pandemic influenza A H1N1 2009 infection: European case series and review. Eur J Pediatr. 2011 Aug;170(8):1007-15. doi: 10.1007/s00431-010-1392-3.

Mastrolia MV, Rubino C, Resti M, et al. Characteristics and outcome of influenza-associated encephalopathy/encephalitis among children in a tertiary pediatric hospital in Italy, 2017-2019. BMC Infect Dis. 2019 Nov 29;19(1):1012. doi: 10.1186/s12879-019-4636-5.

Akins PT, Belko J, Uyeki TM, et al. H1N1 encephalitis with malignant edema and review of neurologic complications from influenza. Neurocrit Care. 2010 Dec;13(3):396-406. doi: 10.1007/s12028-010-9436-0.

Takia L, Saini L, Keshavan S, et al. Neurological Manifestations of Influenza A (H1N1): Clinical Features, Intensive Care Needs, and Outcome. Indian J Pediatr. 2020 Oct;87(10):803-809. doi: 10.1007/s12098-020-03297-w

Pérez-Rubio G, Ponce-Gallegos MA, Domínguez-Mazzocco BA, Ponce-Gallegos J, García-Ramírez RA, Falfán-Valencia R. Role of the Host Genetic Susceptibility to 2009 Pandemic Influenza A H1N1. Viruses. 2021 Feb 22;13(2):344. doi: 10.3390/v13020344.

Ninove L, Daniel L, Gallou J, et al. Fatal case of Reye's syndrome associated with H3N2 influenza virus infection and salicylate intake in a 12-year-old patient. Clin Microbiol Infect. 2011 Jan;17(1):95-7. doi: 10.1111/j.1469-0691.2010.03196.x.

Poddar U, Vadlapudi SS. Reye Syndrome - An Enigma That Remains. Indian Pediat. 2023 Jun 15;60(6):486-487.

Chapman J, Arnold JK. Reye Syndrome. [Updated 2023 Jul 4]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK526101/




DOI: http://dx.doi.org/10.14748/ssm.v57i1.10223
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About The Authors

Yana Deyanova
Medical University of Varna
Bulgaria

Department of Pediatrics, Faculty of Medicine;

First Pediatric Clinic with PICU, St. Marina University Hospital, Varna

Darina Krumova
Medical University of Varna
Bulgaria

Department of Pediatrics, Faculty of Medicine;

First Pediatric Clinic with PICU, St. Marina University Hospital, Varna

Darina Zlatkova
Medical University of Varna
Bulgaria

First Pediatric Clinic with PICU, St. Marina University Hospital, Varna

Mergyul Halilova
Medical University of Varna
Bulgaria

Department of Pediatrics, Faculty of Medicine;

First Pediatric Clinic with PICU, St. Marina University Hospital, Varna

Miryana Kondakova
Medical University of Varna
Bulgaria

Department of Imaging Diagnostics and Interventional Radiology, Faculty of Medicine

Jivka Demireva-Kalcheva
Medical University of Varna
Bulgaria

Department of Microbiology and Virology, Faculty of Medicine

Violeta Iotova
Medical University of Varna
Bulgaria

Department of Pediatrics, Faculty of Medicine;

First Pediatric Clinic with PICU, St. Marina University Hospital, Varna

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