A study of the frequency and localization of the gastroenteropancreatic neuroendocrine tumors diagnosed and operated at the University hospital - Pleven in 2014

Abstract

Objective: Over 90% of neuroendocrine tumors (NETs) in Bulgaria were reported to arise in the gastrointestinal tract. Our objective was to study the incidence and localization of the gastroenteropancreatic NETs, diagnosed for one year.
Methods: The present retrospective study explores the incidence and localization of the gastroenteropancreatic NETs, diagnosed and operated for one year period (during 2014) in UMHAT `Dr. Georgi Stranski`, Pleven.
Results: Seven cases of gastroenteropancreatic NETs were diagnosed and treated for the studied period. Most common primary sites were: pancreas in 4 (57.14 %) cases and 2 in colon (28.57 %) cases. According to the morphological criteria, 2 (28.57 %) were well differentiated NETs, 3 (42.86 %) were moderately differentiated, and 2 (28.57 %) were poorly differentiated NETs. One of them was mixed adenoneuroendocrine carcinoma. All cases demonstrated immunoexpression of Chromogranin A and Synaptophysin in addition to the distinct neuroendocrine morphology. Distant site metastases were observed in 5 (71.43 %) cases.
Conclusion: According to our results, most of the gastroenteropancreatic NETs were well and moderately differentiated and located in pancreas. A considerable number of patients had distant metastasis at the time of diagnosis. The expression of Chromogranin A and Synaptophysin supported the morphological diagnosis of gastroenteropancreatic NET.