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Migraine and Cardiovascular Disorders

D. Minchev


From a clinical point of view, differentiation of numerous forms of migraine depends on the accompanying diseases with prevailing cardiovascular symptoms. However, many pathophysiological interactions between migraine and cardiovascular disturbances remain insufficiently clarified yet. The low relative share of myocardial infarction im migraine patients along with the higher one of angina pectoris results from the coronary spasm accompanying every migraine fit and from the increased arterial resistance. There is a familial predisposition between migraine and Raynaud's disease, systemic lupus erithematosus, and acute myocardial infarction as risk factor for the manifestation of migraine fits. Coronary ischemia plays an important role in these cases and requires the discussion of an adequate therapeutic and protective approach


Migraine; Cardiovascular Disorders; Coronary Ischemia; Hypertension; Migraine Treatment

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Белоев , И ., H. Узунов . ЕКГ-проучвания при мигрената.- В: Втори конгрес по неврология, психиатрия и неврохирургия. София, 5-8.X. 1971 г. София, Медицина и физкултура, 1973, 147-175.

Поспелова , Г. H., M. Н. Жильцова , А. А. Малинова. Осцилографические и капилляроскопические показатели при мигрени - В: Головные боли. Труды симпозиума. Москва, 1964.

П р у си н с ки й , А . Мигрень. Москва, Медицина, 1979. 200 с.

У зу н о в , Н. Загадките на мигрената. Същност и нова концепция за лечение. София, Булгарика, 1995, 132 с.

Х адж и е в , Д ., Г. Митев. Мигрена - диагноза, лечение, профилактика. София, Медицина и физкултура, 1995, 86.

D av ie s, P. T ., R. C. P e a tfie ld , T. J. S te in e r, R. Л. Bond, F. C liffo rd -R o s e . Some clinical comparisons between common and classical migraine: a questionnaire-based study.- Cephalalgia, 11, 1991, No 5, 223-227.

Dixon, R. M., H. B. M e ire , D. H. Evans, H. Watt. N. On, J. P o sn e r, P. E. Rolan. Peripheral vascular effects and pharmacokinetics of the anlimigraine compound, zolmitriptan, in combination with oral ergotamine in healthy volunleers.- Cephalalgia, 17. 1997. No 6, 639-646.

F itz -H a u g h , J. R. T. Precordial migraine: an important form of angina innocens.- New Int. Clin., 1,

, 141-147.

K e lly , K. M. Cardiac arrest following use of sumatriptan.- Neurology, 45, 1995, No 6, 1211-1213.

K h o sh b in , Sh. Migraine is more prevalent among systemic lupus erythematosus patients.- JAMA, Migraine information Center, AASN. 1999, 51, 1-2.

K u ritz k y , A. Migraine may reduce risk of acute myocardial infarction.- JAMA, Migraine Information

Center, AASN, 1998,40, 1-2.

L e o n -S o tom a y o r, L. A. Cardiac migraine – report o f twelve cases.- Angiology, 25, 1974, No 3, 161-171.

Mikano, K., T. T ak a sh im a , K. T ak a h a sh i. Cardiovascular sympathetic hypofunction in muscle

contraction headache and migraine.- Headache, 29, 1989, No 2, 86-89.

M u e lle r, L., R. M. C a lla g h e r, C. A. C lerv e. Vasospasm-induced myocardial infarction with sumatriptan.- Headache, 36, 1996, No 5, 329-331.

P ro ra n d c ll, C., P. P a rc h i, C. B a rle tta , M. C h lo g a , E. L u g a re s t, P. C o rd il. Power spectral

analysis o f heart and diastolic blood pressure variability in migraine with and without aura.- Cephalalgia, 17, 1997, No 7, 756-760.

Radot, P . V. Rapport sur la pathogenic de la migraine. 25.V. 1925,- Rev. Neurol.. 43, 1925, No 6, 881-922.

R adot, P. V., P. B lam o u tie r. Syndrome de vasodilatation hemicephalique d'origine sympathique,

(hemicranic, hemihydrorrhee nasale, hemilarmoiement).- Bid!. Soc. Med. Hop. (Paris), 49 1925. 1488-1493.

Ries. S ., W. S te in k e . W. N e ff. C. S c h in d lm a y r, S. M e ia irs , M. H e n n e ric i. Ischemia-induced migraine from paradoxical cardioemboli stroke.- Eur. Neurol, 36, 1996, No 2,76-78.

S a ck s , O. Migraine: the evolution of a common disorder. London, Faber and Faber, 1970.

Sm y th , V., A. W in ter. The EEC in migraine.- In: Int. Congr. Ser., Excerpta Medica, 37, 1961, 15-17.

T h om a s, W. A., W. E. Post. Paroxysmal tachycardia in migraine.- JAMA. 84. 1925, No 8, 569-570.

W a lk e r. C. Migraine and its relationship to hypertension.- Br. Med. J., 2. 1959, No 5164, 1430-1433.

Van den B rin k , A. Coronary side-effect potential of current and prospective antimigraine drugs.- Circulation. 98, 1998, No 1,25-30.

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D. Minchev


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