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Toxicological Patterns of Multicomponent Polymer Systems

R. Cherkezova, S. Racheva, A. Topliyska, S. Pavlov, Z. Zlatev


Development of new polymer systems (PS) based on thermo-active resins is important not only from a chemical viewpoint but also because of the opportunity for programmable changing their properties and subsequent application in clinical practice. Some chemical features of a new composition for a multicomponent polymer system (MPS) based on hydrophilized unsaturated polyester resin (HUPR) are presented. Strength parameters of several resins of different compositions are examined. The analysis of the acute oral toxicity of these resins in white Wistar rats proves that they are low toxic. These PS do not demonstrate any harmful effects on human skin after the predicting irritation and sensitization tests using epicutaneous samples. Their main advantages include preliminary water-solubility and capacity to incorporate water, good dilution into water and resin water dispersions, porosity, low relative mass, high strength indices, improved ecological features, thin-founding capacity, good relief impressions in combination with high adhesion ability towards wet surfaces. A wide MPS usage in the manufacture of orthopedic plaster dressings, prostheses, splints, insoles, positive-sample dental imprints, and casts is recommended.


Multicomponent Polymer Systems; Hydrophilized Unsaturated Polyester Resin; Skin Toxicology

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About The Authors

R. Cherkezova


R. Cherkezova, Dept, of Medical Physics, Chemistry and Biology, Prof. Paraskev Stoyanov Medical University of Varna, 55 Marin Drinov Street, BG-9002 Varna Bulgaria

S. Racheva


A. Topliyska


S. Pavlov


Z. Zlatev


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